zonula occludens

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zo·nu·la oc·clu·'dens

tight junctions formed by the fusion of integral proteins of the lateral cell membranes of adjacent epithelial cells, limiting transepithelial permeability.

Synonym(s): impermeable junction, tight junction

zonula occludens

Etymology: L, zona, belt, occludere, to close up

a component of the junctional complex between cells in which there is no intercellular space and the plasma membranes of adjacent cells are in direct contact.

zonula

(zon'yu-la) [L. zonula, little girdle]

A small zone. Synonym: zonule

zonula adherens

The portion of the junctional complex between columnar epithelial cells below the zonula occludens where there is an intercellular space of about 200 A.U. and the cellular membranes are supported by filamentous material.

zonula ciliaris

Ciliary zonule.

zonula occludens

Tight junction.

zonula

pl. zonulae [L.] zonule.

zonula adherens

common component of junctional complexes between epithelial cells; forms an effective barrier between the lumen and connective tissue. Called also tight junction.

zonula ciliaris

suspensory ligament of the lens.

zonula occludens

part of the junctional complex of columnar epithelium.

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References in periodicals archive ?

Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

Rhubarb Monomers Protect Intestinal Mucosal Barrier in Sepsis via Junction Proteins

They bind to the intracellular proteins zonula occludens (ZO)-l, ZO-2, cingulin, and/or 7H6 that couple the TJs to the actin cytoskeleton of endothelial cells (Abbott et al.

Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation

In addition, the down modulation of expression of members of tight junction proteins such as zonula occludens (ZO-1), occludin, and P-glycoprotein (P-gp), a transmembrane glycoprotein located on the apical/luminal membrane of brain microvascular endothelial cells (BMVEC) that transports endothelium-penetrating lipophilic molecules back into the blood were found in SCID mouse model of HIVE.

Cellular & molecular basis of HIV-associated neuropathogenesis

Morphological factors influencing transepithelial permeability: A model for the resistance of the zonula occludens.

Morphology and Epithelial Ion Transport of the Alkaline Gland in the Atlantic Stingray (Dasyatis sabina)

In addition, GLP-2 could recover and maintain the integrity of the intestinal mucosa epithelium barrier by increasing the expressions of zonula occludens protein 1 (ZO-1), claudin-1 and occludin in obstructive jaundice rats (Chen et al.

The effects of glucagon-like peptide-2 on the tight junction and barrier function in IPEC-J2 cells through phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling pathway

TJP2 , also known as ZO2 , encodes the zonula occludens 2, which belongs to the family of the membrane-associated guanylate kinase homolog with three PDZ domains, one SH3 module, and a GuK domain.

Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment

One of the critical proteins ensuring the functionality of tight junctions is called zonula occludens 1 (ZO-1), and disrupted ZO-1 complexes are strongly correlated with increased intestinal barrier permeability (Walker and Porvaznik 1978).