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CA.1afa.5AA gene on chromosome 16p24.3 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. Carbonic anhydrase 5A is localised in mitochondria, expressed primarily in the liver and may play an important role in ureagenesis and gluconeogenesis.
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(chemotherapeutic agents to treat bone, lung, and other cancers.
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