zinc finger

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zinc fin·ger

a zinc-binding domain in a protein structure often seen in certain gene regulatory proteins, for example, transcription factors.
A small tertiary protein structural motif of higher organisms, in which parts of a protein fold around a zinc molecule, acting as a hook to attach activator proteins to DNA; the ZF motif is present in many proteins that regulate expression of eukaryotic genes—e.g., proto-oncogenes, Wilms’ tumour gene, growth signal receptors

zinc finger

a finger-like structure that is found in specific DNA binding PROTEINS, where the DNA binding DOMAIN of the protein complexes zinc. Zinc fingers are found in various eukaryotic TRANSCRIPTION factors, which have a role in controlling the transcription of specific GENES.
References in periodicals archive ?
Approximately 3% of the mammalian genome codes for Zn finger proteins (Auld, 2009).
The polypeptide chain forms a curl or 'finger' usually of 11-13 amino acid residues that links the specific sequences of DNA (Zn finger motif).
OVOL1 regulates transcription in the nucleus by binding to p300, which is a member of the histone acetyltransferase (HAT) family and contains the Zn finger motif [42].
Furthermore, the expression of several KLK-related peptidases, including KLK5 and KLK7, is negatively regulated by transcriptional factor specificity protein 1 (Sp1), a C2H2-type Zn finger protein [52].
Five of these genes encode Zn finger proteins (ZBTB1, ZNF44, BCL6, ZNF436) or proteins containing Zn-binding domains (PML) that play a role in DNA binding (Bray et al.
TNFAIP3 (A20) is a Zn finger protein that is rapidly induced by TNF.
The majority of intracellular Zn exists in a tightly bound form most commonly associated with metalloproteins and Zn finger proteins.