Approximately 3% of the mammalian genome codes for Zn finger proteins (Auld, 2009).
The polypeptide chain forms a curl or 'finger' usually of 11-13 amino acid residues that links the specific sequences of DNA (Zn finger motif).
OVOL1 regulates transcription in the nucleus by binding to p300, which is a member of the histone acetyltransferase (HAT) family and contains the Zn finger motif .
Furthermore, the expression of several KLK-related peptidases, including KLK5 and KLK7, is negatively regulated by transcriptional factor specificity protein 1 (Sp1), a C2H2-type Zn finger protein .
Five of these genes encode Zn finger proteins (ZBTB1, ZNF44, BCL6, ZNF436) or proteins containing Zn-binding domains (PML) that play a role in DNA binding (Bray et al.
TNFAIP3 (A20) is a Zn finger protein that is rapidly induced by TNF.
The majority of intracellular Zn exists in a tightly bound form most commonly associated with metalloproteins and Zn finger