zinc finger

(redirected from Zinc fingers)
Also found in: Encyclopedia.

zinc fin·ger

a zinc-binding domain in a protein structure often seen in certain gene regulatory proteins, for example, transcription factors.
Farlex Partner Medical Dictionary © Farlex 2012
A small tertiary protein structural motif of higher organisms, in which parts of a protein fold around a zinc molecule, acting as a hook to attach activator proteins to DNA; the ZF motif is present in many proteins that regulate expression of eukaryotic genes—e.g., proto-oncogenes, Wilms’ tumour gene, growth signal receptors
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

zinc finger

a finger-like structure that is found in specific DNA binding PROTEINS, where the DNA binding DOMAIN of the protein complexes zinc. Zinc fingers are found in various eukaryotic TRANSCRIPTION factors, which have a role in controlling the transcription of specific GENES.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
OVO-like proteins (OVOLs) are transcribed from ubiquitously conserved genes encoding a C2H2 zinc finger transcription factor in mammals [37].
Because KLF6-SV1, lacks the binding domain DNA, called "zinc fingers", there is no transactivation of p21 and E-cadherin genes, which are required for the KLF6 tumor suppressor function (Narla et al., 2001; DiFeo et al., 2006).
The design and application of ZFNs involve modular design, assembly, and optimization of zinc fingers against specific target DNA sequences followed by linking of individual ZFs towards targeting larger sequences.
Interestingly, the comparison of the UV-Vis spectra of Ros87_C27D with those reported in literature for zinc fingers with [Cys.sub.2][His.sub.2], [Cys.sub.3]His, and [Cys.sub.4] coordination outlines a blue shift of the d-d transition bands of the protein that uses a single cysteine to coordinate the metal ion [48] (Figure 2).
Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition.
CCCH-type zinc finger (ZF) proteins are RNA-binding proteins with regulatory functions at all stages of mRNA metabolism.
These "zinc finger nucleases" can be used like molecular scissors to introduce intentional genetic mutations.
Along with a technique called TALENs, invented several years ago, and a slightly older predecessor based on molecules called zinc finger nucleases, CRISPR could make gene therapies more broadly applicable, providing remedies for simple genetic disorders like sickle-cell anemia and eventually even leading to cures for more complex diseases involving multiple genes.
KRAB-containing proteins are transcriptional repressors and use the zinc fingers to bind DNA [29].
ZNF521/EHZF is a large multifunctional protein with 30 zinc fingers, identified in our laboratory for its selective abundance in immature hematopoietic progenitors compared to mature leukocytes [5, 6].
The predicted NtCO1 protein contains two B-box-type zinc fingers and a CCT domain.
Recently, Afr1 was identified as zinc fingers and homeoboxes 2 (ZHX2).

Full browser ?