EGR1

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EGR1

A gene on chromosome 5q31.1 that encodes a DNA-binding nuclear protein of the EGR family of C2H2-type zinc-finger transcriptional regulators. EGR1 activates the transcription of target genes whose products are required for mitogenesis and differentiation.
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References in periodicals archive ?
French et al., "A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories," Nature Neuroscience, vol.
Laroche, "How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning?" Behavioural Brain Research, vol.
Suarez et al., "D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-induced arc and zif268 expression in the hippocampus," Cerebral Cortex, vol.
Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268. The Journal of Neuroscience, 21, 5089-6098.
D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-induced are and zif268 expression in the hippocampus.
* Sidarta Ribeiro et al established that not only do we have specific gene expression during the dreaming state, but that a particular immediate early gene, zif268, is expressed in dreaming that follows interesting, novel and meaningful experience during the previous day (Ribeiro et al, 1999; Ribeiro et al, 2002).
Superoxide radicals are mediators of the effects of methamphetamine on Zif268 (Egr 1, NGFI-A) in the brain: evidence from using CuZn superoxide dismutase transgenic mice.
These include dopamine, (39) vasoactive intestinal peptide, (40) nitric oxide, (41) retinoic acid, (42) the immediate early gene zif268, Egr-1 (ZENK), (43) basic fibroblast growth factor (bFGF), tissue growth factor b (TGFb) (44) and others.