Zinc Finger Protein

(redirected from Zfp)
Also found in: Acronyms.
Any of a superfamily of transactivating protein receptors that mediate the actions of steroids and steroid-like hormones; after a zinc finger receptor binds a hormone, it influences gene expression by associating with specific DNA elements, the hormone-responsive elements (HREs)


a chemical element, atomic number 30, atomic weight 65.37, symbol Zn. See Table 6.
Zinc is a trace element that is a component of several enzymes, including DNA and RNA polymerases, and carbonic anhydrase. Zinc salts are used in skin lotions, eye washes, the treatment and prevention of footrot of sheep and facial eczema of sheep and cattle.

zinc acetate
a salt used as an astringent and styptic.
zinc cadmium sulfide
used in the preparation of fluoroscopic screens; is fluorescent and emits yellow-green light when excited by x-rays.
zinc carbonate
a mild astringent; used mainly as calamine.
zinc chromate
an industrial compound used in cold galvanizing of metal. Accidental access causes diarrhea and fatal enteritis.
zinc finger motif
sequence of approximately 30 amino acids, forming a helix-turn-helix, believed to form a structure that includes tetrahedrally coordinated zinc (II) ions. Found in many eukaryotic, prokaryotic and viral DNA-binding proteins.
zinc finger protein
DNA-binding proteins that contain zinc-finger motifs.
zinc gelatin
a mixture of zinc oxide, gelatin, glycerin and purified water; used topically as a protectant.
zinc gluconate
a source of supplementary zinc.
hereditary zinc deficiency
lethal trait A46; see inherited parakeratosis.
zinc nutritional deficiency
causes parakeratosis in pigs, a chronic, afebrile, noninflammatory disease of the epidermis characterized by crusty proliferation and cracking of the skin. Dogs fed diets with high levels of calcium or cereals may have poor absorption of zinc and develop signs of deficiency, primarily in the skin. See also zinc-responsive dermatosis.
zinc ointment
a preparation of zinc oxide and mineral oil in white ointment; used topically as an astringent and protectant.
zinc oversupplementation
causes hemolytic anemia, anorexia and vomiting.
zinc oxide
a compound used as a topical astringent and protectant. Inhalation of fumes causes interstitial emphysema and atelectasis.
zinc phosphate
used as a phosphate-bonded cement in restorative dentistry.
zinc phosphide
used at one time as a rodenticide. When ingested the poisonous gas phosphine is liberated and kills the animal without diagnostic signs or lesions.
zinc poisoning
is usually chronic and causes stiffness and lameness with particular involvement of the shoulder joint in which there is a degenerative arthritis. In acute poisoning there is gastroenteritis with vomiting.
zinc-responsive dermatoses
see parakeratosis, zinc-responsive dermatosis.
zinc stearate
a compound of zinc with stearic and palmitic acids; used as a water-repellent protective powder in dermatoses.
zinc sulfate
a compound used as an ophthalmic astringent, in skin lotions (see white lotion), for sheep footrot, and the treatment of facial eczema. It is the common form of zinc for oral supplementation and treatment of zinc-responsive diseases.
zinc sulfate flotation test
used to demonstrate nematode eggs, protozoan cysts, and larvae in feces and bronchial secretions.
zinc sulfate turbidity test
1. serum globulins are precipitated by zinc sulfate. The test is used for the semiquantitative assessment of the immunological status of foals and calves when there is a question of whether they have suckled to receive immunoglubulins.
2. an outdated liver function test.
zinc undecylenate
a compound used topically in 20% ointment as an antifungal agent. See also undecylenic acid.
References in periodicals archive ?
Fadi Hani, managing director, Avaya Saudi Arabia, remarked: "With the deployment of the Avaya VSP 9000, ZFP is one of the Kingdom of Saudi Arabia's first adopters of a next-generation virtualised data centre.
Dow AgroSciences announces early exercise of commercial license for ZFP technology.
Todos estos procesos de activaci on de genes y control son muy probablemente regulados en gran parte por la expresion de factores de trascripcion como los genes MYB y ZFP.
The use of Sangamo's ZFP technology to enable the efficient and reproducible generation of combinations or stacks of multiple traits and the insertion of new traits could address increasing demand, the company said.
Since the over-expression or under-expression of individual genes is the basis for many diseases, the ability to regulate genes with engineered ZFPs has enormous potential therapeutic benefit.
The company has ongoing Phase 2 and Phase 1/2 clinical trials to evaluate the safety and efficacy of a novel ZFP Therapeutic for the treatment of HIV/AIDS.
SGMO) said on May 21 that data from clinical, preclinical and research-stage programs focused on the development of ZFP Therapeutics for HIV/AIDS, monogenic diseases and stem cell applications, were described in twelve presentations given by Sangamo scientists and collaborators at the recent American Society of Gene and Cell Therapy annual meeting in Philadelphia.
Estas ultimas se alinean con el fallamiento dextral de la peninsula Burica y la falla Canoas, asi como la ZFP.
Proceeds will be used by the company for working capital, general corporate purposes, continuing research and development of ZFP Therapeutic product candidates, research programmes, manufacturing capabilities for clinical and commercial production, clinical trials and business development activities as well as acquisitions of businesses, products, technologies or licenses.
The company's in-vivo protein replacement platform utilises a highly expressed and liver specific genomic "safe-harbor site", which can be edited with ZFP nucleases (ZFNs) to accept and express any therapeutic gene, enabling the continuous production of high levels of the missing protein with a single treatment.
The study, published in Nature, further highlights the precision and broad applicability of ZFN-based genome-editing for the development of ZFP Therapeutics for the treatment of monogenic diseases, the company said.