Zebrafish


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An experimental organism—Brachydanio rerio—which has proven useful for studying vertebrate development, via the strategy of saturation mutagenesis; zebrafish have transparent embryos, short generation time—3 months—and prolific egg production
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developed the zebrafish embryo teratogenicity (ZET) assay (Brannen et al., 2010), which used 24-well plates, dechorionated eggs, and embryos exposed statically from 4-6 hpf up to 5 days post-fertilization (dpf).
(2016), the methodology for toxicity tests employing zebrafish embryos varies greatly between laboratories, with differences in the strain of fish used, timing and frequency of exposure, status of the chorion, exposure apparatus, endpoints measured, and scoring of phenotypic alterations.
The Tropical 5D line of zebrafish (Danio rerio) were purchased from 5D Tropical, Inc.
The 1 ng/mL concentration was selected to match our previously published TCDD exposure paradigm and results in 99-100% of 120-hpf zebrafish displaying the expected TCDD-induced toxicity phenotype (e.g., cartilage and heart malformations and edema) and an approximate log2(fold change) of -1 in sox9b expression (Garcia et al.
After 47 days, none of the adult zebrafish appeared to be damaged but several of their embryos were found to have malformations or abnormalities.
Despite this knowledge, little is known of how the absence of skin pigmentation in TLN zebrafish affects social interactions and the formation of dominance relationships, or how the lack of skin pigmentation influences the activation pattern of escape and swim behaviors.
Here, we conducted a comparative analysis of the social behavior and motor activation pattern of the escape and swim behaviors between WT and TLN zebrafish. We show that TLN fish can form stable social hierarchies, albeit with a higher prevalence of social instability.
Therefore, in this study, we exposed developing zebrafish embryos to a range of low, environmentally relevant, concentrations of inorganic mercury (100 to 400 ppb or [micro]g/liter), in the form of mercuric chloride ([H.sub.g][Cl.sub.2]).
At six hpf, two to four zebrafish embryos were placed in each well.
In a series of assays, the researchers looked at abamectin's effect on zebrafish during early developmental stages.
In contrast to c-Fos, Egr-1, and NPY-R, an ortholog for the immediate-early gene Arc has not been detected in zebrafish. In rodents, Arc is expressed in neocortical and hippocampal neurons, and its activity-dependent expression is absolutely critical for LTP and LTD (Guzowski et al.
The current study was conducted to further characterize the molecular dynamics in the adult zebrafish brain, particularly as they relate to the field of learning and memory.