ZAP-70

(redirected from Zap-70 protein-tyrosine kinase)

ZAP-70

(zap),

ZAP-70

A tyrosine kinase normally expressed in T cells and NK cells. The gene for ZAP-70 is differentially expressed in patients with or without mutations of the gene for IgVH. This provides a valuable prognostic guide as to whether chronic lymphocytic leukaemia is likely to have a good or a poor outcome. ZAP-70 protein levels are can be measured much more easily than the mutational state of the IgVH gene. Zap-70 is a strong predictor of the need for treatment in B-cell chronic lymphocytic leukaemia.
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