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Related to Zantac: ranitidine, Xanax, Zantac 150

ranitidine hydrochloride

Acid Reducer (CA), Apo-Ranitidine (CA), Co Ranitidine (CA), Gavilast (UK), Histac (UK), Raciran (UK), Ranitil (UK), Rantek (UK), Zantac, Zantac 75, Zantac EFFERdose

Pharmacologic class: Histamine2-receptor antagonist

Therapeutic class: Antiulcer drug

Pregnancy risk category B


Reduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating a protective coating on gastric mucosa


Capsules (liquid-filled): 150 mg, 300 mg

Solution for injection: 25 mg/ml in 2-, 6-, and 40-ml vials

Solution for injection (pre-mixed): 50 mg/50 ml in 0.45% sodium chloride

Syrup: 15 mg/ml

Tablets: 150 mg, 300 mg

Tablets (effervescent): 150 mg

Indications and dosages

Active duodenal ulcer

Adults: 150 mg or 10 ml P.O. b.i.d., or 300 mg or 20 ml P.O. daily, or 50 mg I.V. or I.M. q 6 to 8 hours

To maintain healing of duodenal ulcers

Adults: 150 mg or 10 ml P.O.

Benign gastric ulcer

Adults: 150 mg or 10 ml P.O. b.i.d. For maintenance, 150 mg or 10 ml P.O. or 50 mg I.V. or I.M. q 6 to 8 hours.

Active duodenal and gastric ulcers

Children ages 1 month to 16 years: 2 to 4 mg/kg/day P.O., up to a maximum of 300 mg/day

To maintain healing of duodenal and gastric ulcers

Children ages 1 month to 16 years: 2 to 4 mg/kg/day P.O., up to a maximum of 150 mg/day

Erosive esophagitis

Adults: 150 mg or 10 ml P.O. q.i.d.

Children ages 1 month to 16 years: 5 to 10 mg/kg P.O. daily in two divided doses

Gastroesophageal reflux disease

Adults: 150 mg or 10 ml P.O. b.i.d.

Children ages 1 month to 16 years: 5 to 10 mg/kg P.O. daily in two divided doses

Pathologic hypersecretory conditions, including Zollinger-Ellison syndrome

Adults: 150 mg or 10 ml P.O. b.i.d., adjusted according to patient's needs. In severe cases, up to 6 g/day may be needed. Continue therapy as long as indicated.

Hospitalized patients with pathologic hypersecretory conditions, including Zollinger-Ellison syndrome; intractable duodenal ulcers; patients who can't receive oral drugs

Adults: 50 mg I.M. q 6 to 8 hours, or 50 mg intermittent I.V. bolus q 6 to 8 hours, or 50 mg intermittent I.V. infusion q 6 to 8 hours.

Children ages 1 month to 16 years: 2 to 4 mg/kg/day I.V. in divided doses q 6 to 8 hours, up to a maximum of 50 mg q 6 to 8 hours

Dosage adjustment

• Renal or hepatic impairment

• Debilitated patients

Off-label uses

• Asthma

• GI hemorrhage

Helicobacter pylori infection

• Short-bowel syndrome

• Immunosuppression reversal

• Psoriasis

• Aspiration pneumonitis prophylaxis


• Hypersensitivity to drug or its components

• Alcohol intolerance (with some oral products)

• History of acute porphyria


Use cautiously in:

• renal or hepatic impairment, heart rhythm disturbances, phenylketonuria (effervescent tablets)

• elderly patients

• pregnant or breastfeeding patients.


• For intermittent I.V. bolus injection, dilute in normal saline solution or other compatible solution to a concentration not exceeding 2.5 mg/ml. Inject no faster than 4 ml/minute (5 minutes).

• For continuous I.V. infusion in patients with Zollinger-Ellison syndrome, add to dextrose 5% in water (D5W) or other compatible solution; dilute to a concentration not exceeding 2.5 mg/ml, and start infusion at 1 mg/kg/hour. After 4 hours, if measured gastric acid output exceeds 10 mEq/hour or symptoms occur, increase dosage in increments of 0.5 mg/kg/hour, and remeasure acid output.

• Give P.O. doses with or without food. Give once-daily dose at bedtime.

• For intermittent I.V. infusion, dilute in D5W or other compatible solution to a concentration not exceeding 0.5 mg/ml. Infuse no faster than 7 ml/minute (15 to 20 minutes).

• Be aware that premixed Zantac solution of 50 mg in half-normal saline solution (50 ml) doesn't require dilution. Infuse over 15 to 20 minutes.

• Know that I.V. form may be added to total parenteral nutrition solutions.

• Inject I.M. undiluted deep into large muscle.

Adverse reactions

CNS: headache, agitation, anxiety

GI: nausea, vomiting, diarrhea, constipation, abdominal discomfort or pain

Hematologic: reversible granulocytopenia and thrombocytopenia

Hepatic: hepatitis

Skin: rash

Other: pain at I.M. injection site, burning or itching at I.V. site, hypersensitivity reaction


Drug-drug. Antacids: decreased ranitidine absorption

Propantheline: delayed ranitidine absorption and increased peak blood level

Drug-diagnostic tests. Creatinine: slight elevation

Hepatic enzymes: increased levels

Urine protein tests using Multistix: false-negative results

Drug-herbs. Yerba maté: decreased drug clearance

Drug-behaviors. Smoking: decreased ranitidine effects

Patient monitoring

• Assess vital signs.

• Monitor CBC and liver function tests.

Patient teaching

• Tell patient he may take oral drug with or without food. Advise him to take once-daily prescription drug at bedtime.

• Instruct patient to dissolve EFFERdose in 6 to 8 oz of water before taking.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient smoking may decrease drug effects.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.


A trademark for the drug ranitidine.


Ranitidine, see there.
References in periodicals archive ?
Regular Strength Zantac 75 is a nonprescription acid reducer, with 75 mg of the acid-reducer ranitidine available for the relief and prevention of heartburn associated with acid indigestion and sour stomach, according to the company.
Another class of medications is the H2 blockers, including J&J-Merck Consumer Pharmaceutical's Pepcid and Pfizer's Zantac, which work by reducing the amount of acid the stomach produces, resulting in slower but longer-lasting relief for chronic heartburn.
With our Dulcolax line, the Zantac brand will provide Boehringer Ingelheim with significant market presence.
The Zantac family of products prevents and relieves heartburn.
Under the terms of the agreement, Boehringer Ingelheim will purchase all of the rights, title and interest in the O-T-C version of Zantac in the United States.
In addition, private label versions have penetrated all segments of the antacid category, including traditional antacids (as represented by the Tums and Rolaids brands), H2 blockers (led by the branded items Tagamet, Zantac and Pepcid) and liquids (which include the Mylanta and Maalox brands).
The acquisition of the supplier of such over-the-counter drug and personal care brands as Benadryl, Bengay, Desitin, Lubriderm, Nicorette, Rolaids, Sudafed, Visine, Zantac and Listerine is expected to close by year-end.
com/young-sheldon/episode-6-a-patch-a-modem-and-a-zantac-r-guide/) A Patch, A Modem, and a Zantac Guide .
H2 blockers like Zantac and antacids like Rolaids provide additional heartburn treatment options to bring shoppers back into the category," says Jordana Barish, associate director of marketing, upper GI, Sanofi Consumer Healthcare.