Zantac


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Related to Zantac: ranitidine, Xanax, Zantac 150

ranitidine hydrochloride

Acid Reducer (CA), Apo-Ranitidine (CA), Co Ranitidine (CA), Gavilast (UK), Histac (UK), Raciran (UK), Ranitil (UK), Rantek (UK), Zantac, Zantac 75, Zantac EFFERdose

Pharmacologic class: Histamine2-receptor antagonist

Therapeutic class: Antiulcer drug

Pregnancy risk category B

Action

Reduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating a protective coating on gastric mucosa

Availability

Capsules (liquid-filled): 150 mg, 300 mg

Solution for injection: 25 mg/ml in 2-, 6-, and 40-ml vials

Solution for injection (pre-mixed): 50 mg/50 ml in 0.45% sodium chloride

Syrup: 15 mg/ml

Tablets: 150 mg, 300 mg

Tablets (effervescent): 150 mg

Indications and dosages

Active duodenal ulcer

Adults: 150 mg or 10 ml P.O. b.i.d., or 300 mg or 20 ml P.O. daily, or 50 mg I.V. or I.M. q 6 to 8 hours

To maintain healing of duodenal ulcers

Adults: 150 mg or 10 ml P.O.

Benign gastric ulcer

Adults: 150 mg or 10 ml P.O. b.i.d. For maintenance, 150 mg or 10 ml P.O. or 50 mg I.V. or I.M. q 6 to 8 hours.

Active duodenal and gastric ulcers

Children ages 1 month to 16 years: 2 to 4 mg/kg/day P.O., up to a maximum of 300 mg/day

To maintain healing of duodenal and gastric ulcers

Children ages 1 month to 16 years: 2 to 4 mg/kg/day P.O., up to a maximum of 150 mg/day

Erosive esophagitis

Adults: 150 mg or 10 ml P.O. q.i.d.

Children ages 1 month to 16 years: 5 to 10 mg/kg P.O. daily in two divided doses

Gastroesophageal reflux disease

Adults: 150 mg or 10 ml P.O. b.i.d.

Children ages 1 month to 16 years: 5 to 10 mg/kg P.O. daily in two divided doses

Pathologic hypersecretory conditions, including Zollinger-Ellison syndrome

Adults: 150 mg or 10 ml P.O. b.i.d., adjusted according to patient's needs. In severe cases, up to 6 g/day may be needed. Continue therapy as long as indicated.

Hospitalized patients with pathologic hypersecretory conditions, including Zollinger-Ellison syndrome; intractable duodenal ulcers; patients who can't receive oral drugs

Adults: 50 mg I.M. q 6 to 8 hours, or 50 mg intermittent I.V. bolus q 6 to 8 hours, or 50 mg intermittent I.V. infusion q 6 to 8 hours.

Children ages 1 month to 16 years: 2 to 4 mg/kg/day I.V. in divided doses q 6 to 8 hours, up to a maximum of 50 mg q 6 to 8 hours

Dosage adjustment

• Renal or hepatic impairment

• Debilitated patients

Off-label uses

• Asthma

• GI hemorrhage

Helicobacter pylori infection

• Short-bowel syndrome

• Immunosuppression reversal

• Psoriasis

• Aspiration pneumonitis prophylaxis

Contraindications

• Hypersensitivity to drug or its components

• Alcohol intolerance (with some oral products)

• History of acute porphyria

Precautions

Use cautiously in:

• renal or hepatic impairment, heart rhythm disturbances, phenylketonuria (effervescent tablets)

• elderly patients

• pregnant or breastfeeding patients.

Administration

• For intermittent I.V. bolus injection, dilute in normal saline solution or other compatible solution to a concentration not exceeding 2.5 mg/ml. Inject no faster than 4 ml/minute (5 minutes).

• For continuous I.V. infusion in patients with Zollinger-Ellison syndrome, add to dextrose 5% in water (D5W) or other compatible solution; dilute to a concentration not exceeding 2.5 mg/ml, and start infusion at 1 mg/kg/hour. After 4 hours, if measured gastric acid output exceeds 10 mEq/hour or symptoms occur, increase dosage in increments of 0.5 mg/kg/hour, and remeasure acid output.

• Give P.O. doses with or without food. Give once-daily dose at bedtime.

• For intermittent I.V. infusion, dilute in D5W or other compatible solution to a concentration not exceeding 0.5 mg/ml. Infuse no faster than 7 ml/minute (15 to 20 minutes).

• Be aware that premixed Zantac solution of 50 mg in half-normal saline solution (50 ml) doesn't require dilution. Infuse over 15 to 20 minutes.

• Know that I.V. form may be added to total parenteral nutrition solutions.

• Inject I.M. undiluted deep into large muscle.

Adverse reactions

CNS: headache, agitation, anxiety

GI: nausea, vomiting, diarrhea, constipation, abdominal discomfort or pain

Hematologic: reversible granulocytopenia and thrombocytopenia

Hepatic: hepatitis

Skin: rash

Other: pain at I.M. injection site, burning or itching at I.V. site, hypersensitivity reaction

Interactions

Drug-drug. Antacids: decreased ranitidine absorption

Propantheline: delayed ranitidine absorption and increased peak blood level

Drug-diagnostic tests. Creatinine: slight elevation

Hepatic enzymes: increased levels

Urine protein tests using Multistix: false-negative results

Drug-herbs. Yerba maté: decreased drug clearance

Drug-behaviors. Smoking: decreased ranitidine effects

Patient monitoring

• Assess vital signs.

• Monitor CBC and liver function tests.

Patient teaching

• Tell patient he may take oral drug with or without food. Advise him to take once-daily prescription drug at bedtime.

• Instruct patient to dissolve EFFERdose in 6 to 8 oz of water before taking.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient smoking may decrease drug effects.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

Zantac

(zăn′tăk′)
A trademark for the drug ranitidine.

Zantac®

Ranitidine, see there.
References in periodicals archive ?
Vitamin-K injections Fortum, Vancomycine, Zantac, 1/V Fluid with KCL and Calcium Gluconate was given and all possible efforts were made by Doctors, but the child could not survive and expired on 20.02.2019 at 2:20 pm due to Birth Asphyxia and Neonatal Sepsis and Low Birth Weight.
According to Firrell, Zantac sales went up and the company enhanced its reputation where it had been in danger of seeing it tarnished through headlines in the national press.
At the time, generic drug manufacturers were marketing a generic alternative to Zantac. They managed to purchase ranitidine at C$194 to C$304 per kilogram--significantly less than the C$1512 to C$1651 per kilogram Glaxo paid.
While accepting that an arm's length purchaser can always buy an ingredient at market price, the more relevant question in the Court's view was whether that purchaser would be able to sell such a product under Glaxo's Zantac trademark.
They are more potent than other medications such as Zantac or Pepcid that suppress acid production through a different biological mechanism.
Try nonprescription strength H2 receptor blockers (Zantac or Pepcid) taken before running and up to twice a day
Glaxo's lead drug at the time was Zantac, which accounted for one-third of the company's bottom line and was also the world's bestselling ulcer medicine.
Alka-Seltzer, Maalox, Tums, and Rolaids can interfere with the stomach's absorption of Agenerase, Crixivan, Rescriptor, and Reyataz, while Axid, Pepcid, Tagamet, and Zantac should be entirely avoided by those taking Crixivan, Rescriptor, and Reyataz.
A previous study had shown a 30% reduction in blood concentration of amprenavir when Zantac (another drug for reducing stomach acidity) was given one hour before Lexiva [2].
467, 2005) warns against using histamine H2-receptor antagonists (for example, Zantac) when taking the HIV protease inhibitor Lexiva.