ketotifen

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ketotifen

 [ke″to-ti´fen]
a noncompetitive H1-receptor antagonist and mast cell stabilizer; used as the fumarate salt, administered orally in the chronic treatment of children with mild atopic asthma and topically to the conjunctiva as an antipruritic in the treatment of allergic conjunctivitis.

ketotifen

A drug that prevents the release of HISTAMINE and other irritating substances from MAST CELLS in allergic conditions. Its action is similar to that of CROMOGLYCATE (cromoglicate) but has the disadvantage of causing drowsiness. A brand name is Zaditen.

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.
References in periodicals archive ?
This product is a generic version of Zaditor, a sterile ophthalmic solution containing ketotifen for topical administration to the eyes that is indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.
Mice fed a healthy diet improved moderately, while those given either cromolyn or Zaditor showed dramatic improvements.
"We knew from published research that both cromolyn and Zaditor help stabilize mast cells in people suffering from allergy or asthma," said Nature magazine quoted Shi as saying.
Zaditor eye drops differ from other O-T-C allergy eye drops in another way.
+1% Leading brands Dollar sales % Market in drug stores (000) change share Private Label $113,846 + 2.8% 17.8% Alcon Systane Ultra 34,478 + 4.8% 5.4% Alcon Systane 32,169 + 4.5% 5.0% Alcon Opti Free Replenish 26,729 - 12.3% 4.2% Alcon Opti Free Pure Moist 23,155 + 9.1% 3.6% Bausch + Lomb Biotrue 22,442 + 9.2% 3.5% Bausch + Lomb Renu Fresh 18,812 + 3.5% 3.0% Allergan Refresh Optive 16,814 - 6.9% 2.6% Allergan Refresh Tears 16,441 + 12.8% 2.6% Alcon Zaditor 16,438 + 5.3% 2.6% UNIT SALES * Total 212.2 mil.
The company's portfolio of eye care products includes Clearcare Solution, ICAPS eye vitamins, Naphcon-A eye allergy drops, the Opti-Free and Systane brands, and Zaditor Eye Allergy Drops.
Products featured in the program include such Alcon brands as Clear Care solution, ICAPS vitamins, Naphcon-A eye allergy drops, Systane eye drops and Zaditor eye allergy drops.
THE eyeSOLUTION portfolio includes Clear Care Solution, ICAPS eye vitamins, Naphcon-A eye allergy drops, the Opti-Free brand, the Systane brand and Zaditor eye allergy drops.
Alcon's brands include OptiFree, Clear Care in lens care, Systane and Genteal in dry eye, Zaditor, Naphcon A in the eye allergy segment and IC APs ocular vitamins.
(+5.4%) Leading brands Dollar sales % Market in drug stores (000) change share Alcon Opti-Free Replenish $49,559 +4.0% 9.3% Alcon Systane 22779 -5.3% 4.3% Ciba Vision Clear Care 22,655 +13.8% 4.3% Alcon Opti-Free Express 20,806 -8.3% 3.9% Alcon Systane Ultra 19,788 +51.3% 3.7% Clear Eyes 15,385 +29.0% 2.9% GenTeal 13,693 +0.8% 2.6% Zaditor 13,054 +34.0% 2.5% Bausch & Lomb Renu Fresh 11,917 -- 2.2% Similasan 11,212 +2.2% 2.1% UNIT SALES Total * 131 mil.
NEW YORK -- Sales of eye itch/eye redness relievers, one of the leading growth segments of the eye care sector, have been driven by the late 2006 switch of Zaditor (Novartis Pharmaceuticals Corp.) from prescription to over-the-counter status, notes Mike Fleury, national sales manager for Novartis' ophthalmics unit.
The current market is also being affected by the switch to O-T-C status late last year of Zaditor, Novartis Pharmaceuticals Corp.'s product for itchy eyes, which is said to provide up to 12 hours of relief with a single drop.