ZIC3

ZIC3

A gene on chromosome Xq26.2 that encodes a zinc finger protein which acts as a transcriptional activator; it is required in the earliest stages of both axial midline development and left-right asymmetry specification.

Molecular pathology
Defects of ZIC3 cause visceral heterotaxy X-linked type 1 and X-linked VACTERL association.
References in periodicals archive ?
(2015), siliyopati ile iliskili 25 aday genin hedefe yonelik YND ile yaptiklari calismada, 4 olguda ZIC3 geninde, 1 olguda ise FOXF1 geninde mutasyon saptamistir.
Their preferential targets are genes encoding STAT3, ZIC3, and also Oct4, Sox2, and Nanog themselves.
2It has also been reported that Pitx2, lefty-1, lefty-2 and Zic3 genes play a role in asymmetric growth pattern of brain hemisphere.5 Therefore, it is important that more cases of iHME are identified and reported so that further research can be conducted to understand this disorder and develop better treatment strategy.
Pilia et al., "X-linked situs abnormalities result from mutations in ZIC3," Nature Genetics, vol.
Schijvenaars et al., "Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans," American Journal of Medical Genetics, vol.
The top 10 ranked TFs with higher RIF were HAND1, PTK1, NFKB1, ZIC3, STAT6, E2F1, PELP1, USF2, CBFB, SOX9, and FOXO4 (Table 2).
In addition, HAND1, PTK7, and ZIC3 were found to be potential asthma-related factors considering their TIF values.
Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects.
Previous studies have indicated that a number of genes that are regulated by miR-155 are involved in biological processes such as immune response (for instance Pul and SHIP1) inflammation (BACHI and ZIC3) and cell growth/survival (TP53NP1, FOXO3 and GSK3[beta]) (12), (26) (30-35).
Slot/Entity Sub Fields and their extracted values Project Purpose: Project Purpose: Intensive/required professional development in curriculum Study Purpose: to evaluate a novel recombinant Lactobacillus vaccine against HIV Initial Purpose: (1) research activities and (2) public outreach activities Supplement Purpose: (1) directly test the function ofZic3 in node cells in vivo and (2) delineate the requirement of Zic3 in node cells and cilia Project Location: Project Location: within the Quinault Indian Nation Worker Location: 3 remote communities on the Rosebud Sioux Tribe Reservation Facility Location: adjacent to the Tribal Headquarters Site Location: 910 Wrightsboro Road, Augusta.
A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects.
The newfound gene encodes a protein called ZIC3, whose amino acid sequence suggests that it binds to DNA and regulates gene activity.