In addition to SLUG, other transcription factors, such as SNAIL, TWIST, ZEB1, and ZEB2
, may inhibit ECAD transcription and contribute to epithelial-mesenchymal transition (33).
 reported that EZH2 inhibition (not expression) promotes EMT in ovarian cancer cells, whereas its expression represses ZEB2
, which is a main EMT promoting factor .
Reinbold et al., "MicroRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2
and KLF4," Reproductive Biomedicine Online, vol.
Additionally, ZEB1, ZEB2
, vimentin, and snail, genes related to epithelial-to-mesenchymal transition, were decreased after the indoleamine treatment.
AXL has been shown to act through several signaling pathways: activation of NF-[kappa]B and JAK/STAT leads to the regulation of immune response and suppression of inflammation ; in contrast, the activation of transcriptional factors SNAI1/2, ZEB2
, or TWIST stimulates EMT [20, 21]; moreover, AXL mediates tumor invasion by the regulation of matrix metalloproteinase-9 (MMP9) expression .
Komata et al., "Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2
in tumor progression and prognosis," Cancer Science, vol.
The effectiveness of miR-200 sequences in inhibiting EMT were determined by their respective RNA and protein expressions of ZEB1, ZEB2
and E-cadherin, using PCR and Western Blot.
(54) Indeed, cancer cells transfected with mir-200c demonstrated decreased expression of the mesenchymal markers ZEBI, ZEB2
, SNAIL, SLUG, increased expression of the epithelial marker E-cadherin, and decreased invasive capacity of the cells.
showed that miR-132 suppressed the migration and invasion of human non-small-cell lung cancer cells via targeting the EMT- (epithelial-to-mesenchymal transition-) related transcription factor ZEB2
It is known that miR-200 family members can regulate Zeb1 and Zeb2
. MiR-200 can regulate collagen expression and promote the autoregulation of TGF-[beta]1 in murine mesangial cells by inhibiting Zeb1.
miR-192/215 increases E-cadherin expression by repressed translation of ZEB2
, while E-cadherin plays a role restoring the skin barrier integrity.