ZEB1

ZEB1

A gene on chromosome 10p11.22 that encodes a zinc finger transcription factor thought to play a role in transcriptional repression of IL-2.

Molecular pathology
ZEB1 mutations are associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy.
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References in periodicals archive ?
Pituitary tumortransforming gene 1 enhances metastases of cervical cancer cells through miR-3666-regulated ZEB1. Tumour Biol 2015.
NEAT1 contributes to breast cancer progression through modulating miR-448 and ZEB1. J Cell Physiol 2018 [Epub ahead of print].
Tugertimur et al., "The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance," EMBO Molecular Medicine, vol.
Reinbold et al., "MicroRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4," Reproductive Biomedicine Online, vol.
Burk et al., "The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs," Nature Cell Biology, vol.
Additionally, ZEB1, ZEB2, vimentin, and snail, genes related to epithelial-to-mesenchymal transition, were decreased after the indoleamine treatment.
Other genes such as CAST, DOCK9, IL1RN, SLC4A11, HGF, TGFBI, ZNF469, ZEB1, and VSX1 have been studied and involved in the possible genetic element of keratoconus [5, 6].
Xie et al., "DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1," Oncogene, vol.
Cordycepin reduced the expression of the EMT factors in 72 melanoma patient samples comprising HMGA2, Twist1, and ZEB1, and the inhibition of HMGA2 sensitized gastric cancer cells to chemotherapy treatment [178, 179].
A recently described characteristic unique to D-2-hydroxyglutarate is its ability to induce epithelial-mesenchymal transition and metastatic potential in colorectal cancer cells through trimethylation of histone H3 lysine 4 in the promoter region of ZEB1, the gene encoding zinc finger E-box binding homeobox 1, a master regulator of epithelial-mesenchymal transition (45).
Por otra parte, senales inductoras de EMT que provienen del estroma que rodea al tumor primario como el factor de crecimiento de hepatocitos (HGF), el factor de crecimiento epidermico (EGF), el factor de crecimiento derivado de plaquetas (PDGF) y TGF-[beta] se relacionan con la activacion de factores de transcripcion como Snail, Slug, ZEB1, Twist y FOXC2 que ya han sido descritos como esenciales en el desarrollo del proceso neoplasico [4, 5, 6, 7, 8, 9, 10].
In the study, now published online in Nature Cell Biology, researchers from Friedrich-Alexander-UniversitAaAaAeAnt Erlangen-NAaAaAeA rnberg (FAU Germany found that pancreatic cancer cells are able to activate Zeb1, a compound that helps with embryonic development, but is normally dormant in fully developed cells.