Among the 83 TFs, six were differentially expressed: three upregulated ones, that is, zinc finger and BTB domain-containing 7A (ZBTB7A), ovo-like transcriptional repressor 1 (OVOL1), and GATA-binding protein 3, and three downregulated ones, that is, transcription factor dp-1 (TFDP1), SMAD family member 1 (SMAD1), and quiescin sulfhydryl oxidase 1 (QSOX1).
The results suggested that four key pathways (metabolic pathways, TNF signaling pathway, rRNA processing, and cytoplasm), the key gene ICAM1, three miRNAs (hsa-miR7-5p, hsa-miR-433-3p, and hsa-miR-133b), and six TFs (ZBTB7A, OVOL1, GATA3, TFDP1, SMAD1, and QSOX) might play important roles in PD development.
ZBTB7A, OVOL1, and GATA3 were upregulated in patients with PD compared with those in healthy matched controls, whereas TFDP1, SMAD1, and QSOX1 were downregulated.
Evangelou et al., "Gene amplification is a relatively frequent event leading to ZBTB7A (Pokemon) overexpression in non-small cell lung cancer," Journal of Pathology, vol.
Mehanna et al., "ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis," Genes & Development, vol.
19p13.3 microdeletion/duplication syndrome has been previously described within the literature; however, the shortest region of overlap (SRO) is approximately 150 kb and includes one microRNA (SNORD37) and four genes (PIAS4, ZBTB7A
, MAPK2, and partially EEF2).