ZBTB10

ZBTB10

A gene on chromosome 8q13-q21.1 that encodes a protein thought to be involved in regulating transcription.
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References in periodicals archive ?
[sup][13] In breast cancer, miR-27a inhibited the G2-M cell cycle transition by suppressing myelin transcription factor 1 (Myt-1) and zinc finger and BTB domain-containing protein 10 (ZBTB10) and induced cell apoptosis by down-regulating forkhead box O1 (FOXO1).
Por otra parte, miR-27a fue reportado en cancer de seno como un oncomiR que regula el gen ZBTB10 (zinc finger and BTB domain containing 10), un represor de proteinas especificas oncogenicas (Sp).
Angiogenic and proliferative characteristics of breast cancer cells have been associated with overexpression of Sp (37), whereas the zinc finger and BTB domain containing 10 (ZBTB10) gene is regarded as a suppressor of Sp.
[5] Genes: PDCD4, programmed cell death 4 (neoplastic transformation inhibitor); TPM1, tropomyosin 1 (alpha); PTEN, phosphatase and tensin homolog; TIMP3, TIMP metallopeptidase inhibitor 3; SOCS1, suppressor of cytokine signaling 1; ZBTB10, zinc finger and BTB domain containing 10; RHOC, ras homolog gene family, member C; CD44, CD44 molecule (Indian blood group);BRMS1, breast cancer metastasis suppressor 1; SOX4, SRY (sex determining region Y)-box 4; TNC, tenascin C; CDC42, cell division cycle 42 (GTP binding protein, 25kDa); CXCR4, chemokine (C-X-C motif) receptor 4; CYP19A1, cytochrome P450, family 19, subfamily A, polypeptide 1.