Z-finger | definition of Z-finger by Medical dictionary
zinc finger (redirected from Z-finger)
Also found in: Encyclopedia
a zinc-binding domain in a protein structure often seen in certain gene regulatory proteins, for example, transcription factors.
A small tertiary protein structural motif of higher organisms, in which parts of a protein fold around a zinc molecule, acting as a hook to attach activator proteins to DNA; the ZF motif is present in many proteins that regulate expression of eukaryotic genes—e.g., proto-oncogenes, Wilms’ tumour gene, growth signal receptors
a loop of a transcription factor that is stabilized by a zinc ion coordinated with histidine nitrogen atoms or cysteine sulfur atoms at critical junctures in a protein. It is an important step in the cloning and sequencing of human general transcription factors because individual proteins appear to be involved in the regulation of transcription and in RNA transport.
zinc finger a finger-like structure that is found in specific DNA binding PROTEINS, where the DNA binding DOMAIN of the protein complexes zinc. Zinc fingers are found in various eukaryotic TRANSCRIPTION factors, which have a role in controlling the transcription of specific GENES.