In rats, the half-life of TCDD in the body is 31 days, and the half-life of 2,3,4,7,8-pentachlorodibenzofuran (pentaCDF) is 64 days (7,8), but in humans, the reported biological half-life of TCDD in the body is 5.8 years in adults (6) or 11.3 years in soldiers who were veterans of the Vietnam war (9); moreover, the half-lives of 2,3,4,7,8-pentaCDF and 1,2,3,4,7,8-hexachlorodibenzofuran (hexaCDF) are 13.4 years and 12.0 years, respectively, in patients with
Yusho disease who consumed rice oil contaminated with PCDF and polychlorinated biphenyls (PCBs) (10).