Yusho Disease

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A mass poisoning which occurred in northern Kyushu, Japan, in 1968, caused by rice bran oil produced by Kanemi Company in Kyushu, which was contaminated with polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs)
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References in periodicals archive ?
Polychlorinated biphenyls, polychloronated dibenzo-p-dioxins, and polychlorinated dibenzofurans as endocrine we have learned from Yusho disease. Environ Res 86:2-11.
In rats, the half-life of TCDD in the body is 31 days, and the half-life of 2,3,4,7,8-pentachlorodibenzofuran (pentaCDF) is 64 days (7,8), but in humans, the reported biological half-life of TCDD in the body is 5.8 years in adults (6) or 11.3 years in soldiers who were veterans of the Vietnam war (9); moreover, the half-lives of 2,3,4,7,8-pentaCDF and 1,2,3,4,7,8-hexachlorodibenzofuran (hexaCDF) are 13.4 years and 12.0 years, respectively, in patients with Yusho disease who consumed rice oil contaminated with PCDF and polychlorinated biphenyls (PCBs) (10).
Japanese children with Yusho disease, from exposure to high levels of PCBs, showed a high frequency of respiratory symptoms (Nakanishi et al.