YY1


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YY1

A gene on chromosome 14q that encodes a ubiquitous transcription factor belonging to the GLI-Kruppel class of zinc finger proteins, which directs histone deacetylases or histone acetyltransferases to myriad promoters activating or repressing their activity, implicating histone modification in YY1 activity.
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An increase in YY1 activity caused by rapamycin could suppress the production of insulin and related hormones, which are necessary for muscles to take up glucose (sugar) for energy and keep blood sugar levels stable.
The first intron of the mouse [beta]-casein gene contains putative GR, YY1, C/EBP, Oct-1, AP-1 and TATA box (Kolb, 2003).
Dinic et al., "PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells," PLoS ONE, vol.
2009) Flavin-containing [FMO1c-.sub.C-9536A] A (*6): Eliminates monooxygenase (FM01 (rs12720462), in a YY1 binding, 2- to and FM03) promoter region YY1 3-fold loss of binding site promoter activity (Hines et al.
After that, various transcription factors like E2F, YY1, NF[kappa]B, SREBP, Smad7, etc.