YWHAQ

YWHAQ

A gene on chromosome 2p25.1 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif. YWHAQ downregulates PDPK1’s kinase activity.
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Gene Symbol Description FC DLAT Dihydrolipoamide -1,678 S-acetyltransferase HSPB7 Heat shock protein family B -1,422 (small) member 7 LPIN1 Lipin 1 -1,838 MECP2 Methyl-CpG binding protein 2 -1,22 NDUFS3 NADH: ubiquinone oxidoreductase -1,314 core subunit S3 NT5C 5', 3'-nucleotidase, cytosolic -1,524 SIRT5 Sirtuin 5 -1,255 YWHAQ Tyrosine 3-monooxygenase/tryptophan -1,364 5-monooxygenase activation protein theta
10 differentially expressed proteins (YWHAQ (14-3-3), YWHAH (14-3-3), ITGB2 (ITGB2), ACTB (F-actin), PPP2R2A (PP2A), STK3 (Mst1/2), PPP1CA (PP1), CSNK1E (CK1<$/e), NF2 (Mer), and PPP2R1A (PP2A)) were associated with Hippo signaling pathway (Figure 4).
Other proteins such as PPP2R2A, PPP1CA, CSNK1E, and PPP2R1A are involved in the Hippo signaling pathway as the downstream regulator of the core Hpo/Wts kinase cascade, while YWHAQ, YWHAH, ITGB2, and ACTB lead to cell contact inhibition and organ size control.
The remaining group of functional proteins, including YWHAB, YWHAE, YWHAQ, and YWHAZ, that contribute to epilepsy turn out to be encoded by the so-called 14-3-3 family of proteins.