YWHAB

YWHAB

A gene on chromosome 20q13.1 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif. YWHAB downregulates osteogenesis and blocks SRPK2-driven neuronal apoptosis.
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One crucial binding partner of seipin is 14-3-3[beta] (UniProt gene name: YWHAB).
In this study, it was found that peptidylprolyl isomerase A (PPIA), similar to peptidylprolyl isomerase A isoform 1 (LOC654188), transgelin 2 (TAGLN2), and isoform long of 14-3-3 protein beta/alpha (YWHAB) were downregulated, and lamin B1 (LMNB1), Annexin A2 (ANXA2), and Annexin A2-like protein (ANXA2P2) were upregulated in low versus high BMD subjects [40].
The remaining group of functional proteins, including YWHAB, YWHAE, YWHAQ, and YWHAZ, that contribute to epilepsy turn out to be encoded by the so-called 14-3-3 family of proteins.