Analysis of protein-protein interaction: STRING prediction indicated that UTY interacts with heat shock protein 90 kDa alpha, class A member 1 (HSP90AA1); heat shock protein 90 kDa alpha, class B member 1 (HSP90AB1); ubiquitin specific peptidase 9, Y-linked
(USP9Y); lysine (K)-specific demethylase 5D (KDM5D); histone deacetylase 2 (HDAC2); histone deacetylase 1 (HDAC1); histone deacetylase 3 (HDAC3); SET domain containing 2 (SETD2); DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
(DDX3Y) and sex determining region Y (SRY) (Figure 4).
4] Human genes: SRY, sex-determining region Y; TSPY1, testis-specific protein, Y-linked
1; TSPY2, testis-specific protein, Y-linked
2; and TSPY3, testis- specific protein, Y-linked
3; NQO1, NAD(P)H dehydrogenase, quinone 1.
SNP in SRY gene differentiates Chinese indigenous swamp buffalo and introduced river buffalo.
If X-linked drive alleles are normally suppressed by conspecific Y-linked
genes, these suppressors are missing in the hybrid males, who should therefore show meiotic drive.
3] Human genes: TSPY1, testis specific protein, Y-linked
1; SRY, sex-determining region Y.