Analysis of protein-protein interaction: STRING prediction indicated that UTY interacts with heat shock protein 90 kDa alpha, class A member 1 (HSP90AA1); heat shock protein 90 kDa alpha, class B member 1 (HSP90AB1); ubiquitin specific peptidase 9,
Y-linked (USP9Y); lysine (K)-specific demethylase 5D (KDM5D); histone deacetylase 2 (HDAC2); histone deacetylase 1 (HDAC1); histone deacetylase 3 (HDAC3); SET domain containing 2 (SETD2); DEAD (Asp-Glu-Ala-Asp) box polypeptide 3,
Y-linked (DDX3Y) and sex determining region Y (SRY) (Figure 4).
Oura et al., "A
Y-linked anti-Mullerian hormone duplication takes over a critical role in sex determination," Proceedings of the National Academy of Sciences of the United States of America, vol.
[4] Human genes: SRY, sex-determining region Y; TSPY1, testis-specific protein,
Y-linked 1; TSPY2, testis-specific protein,
Y-linked 2; and TSPY3, testis- specific protein,
Y-linked 3; NQO1, NAD(P)H dehydrogenase, quinone 1.
A
Y-linked SNP in SRY gene differentiates Chinese indigenous swamp buffalo and introduced river buffalo.
If X-linked drive alleles are normally suppressed by conspecific
Y-linked genes, these suppressors are missing in the hybrid males, who should therefore show meiotic drive.
For example, the use of a detection target, DYS14 (1, 3), which is a member of a multicopy Y chromosome-specific gene, TSPY1 [3] (testis specific protein,
Y-linked 1), has produced a higher sensitivity in detecting circulating donor-derived DNA than when the single-copy gene SRY (sex-determining region Y) is used (2).
Two candidates, representing genes RPS4Y1 (ribosomal protein S4,
Y-linked 1) and EIF1AY (eukaryotic translation initiation factor 1A,
Y-linked), were detected with reliable signals in all male samples, whereas transcripts for these 2 genes were undetected in all but one female sample.
