xanthine dehydrogenase

Also found in: Acronyms.

xan·thine de·hy·dro·gen·ase

an oxidoreductase oxidizing xanthine to urate with NAD+ as the oxidant. A lower rate of oxidation is observed in individuals with molybdenum cofactor deficiency.
References in periodicals archive ?
Adenosine deaminase, AMP deaminase, 5'-Nucleotidase, Xanthine oxidase and Xanthine dehydrogenase Activities in Prostate Cancer Patients.
a) Interferon and other cytokines increase xanthine oxidoreductase gene (XOR) expression as well as the conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and XOR serum level (reviewed in [11]).
2A lower) while the xanthine dehydrogenase activity remained unchanged (Fig.
Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria.
Coding/regulatory region polymorphism discovery results for aldehyde oxidase, sulfate oxidase, and xanthine dehydrogenase.
The freshly prepared homogenate were then used for determination of thiobarbituric acid reactive substances (TBARS), CAT, GSH, SOD, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), xanthine oxidase (XO), xanthine dehydrogenase (XDH), and uric acid contents.
L: Permissible Exposure Limit Pin1: Prolyl isomerase PP2A: Dephosphorylated by phosphatase A2 Prx: Peroxiredoxin PTB: The phosphor-tyrosine-binding domain QR: Quinone reductase ROS: Reactive oxygen species Shc: Src homologous-collagen SOD: Superoxide dismutase Trx-1: Thioredoxin 1 XD: Xanthine dehydrogenase XO: Xanthine oxidase.
The uric acid concentration is a useful diagnostic marker for deficiencies of phosphoribosyl pyrophosphate synthetase (PRPPS) [4] hypoxanthine guanine phosphoribosyl transferase (HGPRT), purine nucleoside phosphorylase (PNP), xanthine dehydrogenase (XDH), and molybdenum cofactor (2).
The results also revealed that male albino rats fed on a diet containing sodium arsenite NaAsO2 (200mg/kg) for 6 weeks displayed increased activities of serum alkaline phosphatase, g-glutamyl transferase and transaminases and increased malondialdehyde level and xanthine oxidase activity concomitant with a decrease in glutathione level and xanthine dehydrogenase, superoxide dismutase and catalase activities.
This could be due to the fact that the OPCs present in the COC extract may normalize the reducing equivalents in the cell by increasing the glutathione (GSH) pool, which can bring back the enzyme into less reactive native form xanthine dehydrogenase.
When the enzyme is deficient, adenine is not salvaged to AMP, but instead is oxidized to 8-hydroxyadenine and 2,8-dihydroxyadenine by xanthine dehydrogenase (XDH).