xeroderma pigmentosum complementation group C

(redirected from XP-C)

xeroderma pigmentosum complementation group C

A rare autosomal recessive disorder (OMIM:278720) characterised by UV light sensitivity, an increased risk of UV light-induced malignancy and, in some cases, neurologic disease.

Molecular pathology
Defects of XPC, which encodes an early component of the global genome nucleotide excision repair (NER) pathway, cause xeroderma pigmentosum complementation group C.