XLA


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XLA

Abbreviation for X-linked agammaglobulinemia.

BTK

A gene on chromosome Xq21.33-q22 that encodes a protein which plays a central role in B-cell development, differentiation and signalling. Binding of antigens to the B-cell antigen receptor (BCR) triggers signalling that leads to B-cell activation. 

Molecular pathology
Defects of BTK cause X-linked agammaglobulinaemia (OMIM:300755), as well as X-linked hypogammaglobulinaemia and isolated growth hormone deficiency (OMIM:307200).

XLA

Abbreviation for X-linked agammaglobulinemia.
References in periodicals archive ?
One example is the XLA or Bruton's agammaglobulinemia which is a rare genetic disorder with a prevalence of 1 in every 19,000 male births in the United States [13].
We enrolled 7 patients with XLA (17%), ranging in age from 20 months to 18 years; all of them had received routine OPV and are currently undergoing IVIG replacement therapy.
In one case report, it was noted that XLA is also associated with precursor B-cell acute lymphoblastic leukaemia, which is the most common malignancy in children.5 XLA is caused by 600 different mutations in the Bruton tyrosine kinase (Bkt) gene.
No statistically significant difference was found in the rates of lower respiratory tract infection according to the diagnoses of selective IgA deficiency, transient hypogammaglobulinemia of infancy (THI), IgG subgroup deficiency, unclassified hypogammaglobulinemia, XLA, hyper IgM, severe combined immune deficiency (SCID), disorder of neutrophil number and function, hyper IgE and non-PID disease (P>0.05), whereas the rate lower respiratory tract infection was found to be significantly high in children diagnosed with common variable immune deficiency (p<0.05) (Table 6).
The Airforwarders Association (AfA), the National Customs Brokers and Forwarders Association of America (NCBFAA), The International Air Cargo Association (TIACA), and the Express Delivery and Logistics Association (XLA) have jointly sent letters to CBP and the Transportation Security Administration (TSA) noting their support of the concept of the ACAS program's risk-based analysis at the shipment level, but emphasize that "we are concerned about certain issues which we feel have not yet been fully resolved within the ACAS pilot."
Division has introduced and installed a new and more advanced version of the Safe-Slab Core Recycler, the Slabber XLA for nonwovens.
This operation creates a dataset that allows us to compare and build histograms for the sizes of all proteins between two organisms, ZMA and XLA. ZMA is the acronym for Zea mays (maize) and XLA stands for Xenopus laevis (African clawed frog).
(16) Cosneau's edition of the Treaty is based upon two registers from the National Archives, register Xla 8603 (Ordonnances royales) and register JJ171 (tresordes Chartes).
(75) The DMP's discretion to prosecute service offences is a result of the DMP's statutory independence: see DFDA pt XLA. See generally Director of Military Prosecutions, 'Prosecution and Disclosure Policy' (Directive 02/2009, 1 October 2009) 3-7 [10]-[18] <http://www.defence.gov.au/legal/pdf/ddcs/dmp-2-2009.pdf>.
The ERG Lighting division of Endicott Research Group offers the SLD, XLD and XLA Series of LED drivers from GRE Alpha Electronics.
The RN Handy XLA anilox roil cleaning system and AN45 plate cleaning system will be in operation on the stand.
Previously, scientists have always thought that BTK is important primarily in antibody production due to observations made of an inherited genetic disorder in humans called X-linked Agammaglobulinemia (XLA).