XLA


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XLA

Abbreviation for X-linked agammaglobulinemia.

BTK

A gene on chromosome Xq21.33-q22 that encodes a protein which plays a central role in B-cell development, differentiation and signalling. Binding of antigens to the B-cell antigen receptor (BCR) triggers signalling that leads to B-cell activation. 

Molecular pathology
Defects of BTK cause X-linked agammaglobulinaemia (OMIM:300755), as well as X-linked hypogammaglobulinaemia and isolated growth hormone deficiency (OMIM:307200).

XLA

Abbreviation for X-linked agammaglobulinemia.
References in periodicals archive ?
In one case report, it was noted that XLA is also associated with precursor B-cell acute lymphoblastic leukaemia, which is the most common malignancy in children.
The overall design parameters of the Slabber XLA for Nonwovens can be modified to fit a wide variety of installation needs.
The CBA/N inbred mouse strain's X-linked immunodeficiency (xid) has been regarded as an experimental model for human XLA since it was first described in 1972 (91).
Additionally, Dow XLA behaves like the base "rigid fiber" and can be chemically finished in the same manner as the base rigid fiber.
XLA is passed though generations by females, who although they do not show any symptoms, carry the defective genes.
The carrier said that the awards are determined by an annual survey of XLA members who use the services of airlines for their express deliveries around the world.
retailer to use Dow XLA fiber, introducing it in fell 2004 by weaving it into its two-ply cotton shirt to create a new women's fitted shirt that doesn't require ironing.
Dow XLA is a specially-modified, cross linked, olefinic polymer based on Dow's award-winning Insite technology, Dow XLA offers freedom-of-movement to fabrics and garments and is resistant to harsh chemicals and heat.
Branded as the Freedom Fiber, Dow XLA has a heat resistance greater than 220[degrees]C and is resistant to chemicals such as permanganate and hypochlorite.