XIAP


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XIAP

A gene on chromosome Xq25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. XIAP acts by binding to tumour necrosis-factor receptor-associated factors TRAF1 and TRAF2, inhibits apoptosis induced by menadione—a free radical inducer and IL1-beta converting enzyme—and inhibits cell-death proteases caspase-3 and caspase-7.

Molecular pathology
XIAP mutations cause X-linked lymphoproliferative syndrome.
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Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.
Immunochemical detection of XIAP in body cavity effusions and washes.
Examples of cellular IRESes unaffected by eIF2[alpha] phosphorylation are XIAP, c-myc, cationic amino acid transporter-1 (cat-1), and N-myc [38].
Zhu et al., "miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP," Cancer Chemotherapy and Pharmacology, vol.
pylori are associated with cell cycle progression and proliferation (p14, p16, p21, p27, RAB40C, COX 2, FOS, ERBB2, FGFR2, ABL1, ECOP, JAK2, MYC, MET, SIRT1, PDCD4, TRAF6, GMNN, and CCNE2) [213, 223-242], apoptosis (RECK, SMAD4, TRAIL, MCL1, BIM, XIAP, and PDK1) [243-250], and invasion and metastasis (pTEN, WNT 5a, EDNRA, ROR2, EPB41L3, MMP1, MMP10, HMGA2, ROBO1, TGF-[beta], EZH2, casein kinase 2, and ZEB) [251-262].
Usefulness of EMA, GLUT-1, and XIAP for the cytologic diagnosis of malignant mesothelioma in body cavity fluids.
Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism.
We first selected the 36 most important biological modules (CDK4, CDK6, CDK2AP2, BC[L.SUB.2], XIAP, BAX, CASP3, CASP8, CASP9, FOXA2, HNF4A, EBP, HGF, NFKB2, STAT3, IL6, I[L.SUB.1]0, HIF1AN, MYC, GSK3B, TP53, PTEN, RB1, MDM2, PDGFRA, SOX2, PIK3CA, FGFR1, IGF1R, EPHA2, MET, EGFR, DDR2, KEAP1, KRAS, and AKT1) out of the whole genome for lung cancer according to [36].
Further, it is also shown to downregulate the anti-apoptotic proteins Bcl-2, Bcl-xL, inhibitor of apoptosis (IAP) proteins, XIAP, survivin, CIAP-1, and CIAP-2, and increased the expression of pro-apoptotic proteins Bax and Bad.
In addition, inhibitors of apoptosis proteins (IAPs), including survivin and X chromosome-linked IAP (XIAP), also regulate apoptosis [38] Development of HBP tumors is associated with increased cell proliferation, as well as reduced apoptosis of genetically damaged cells; however, due to the increase in cell number, these apoptotic figures are present at higher levels compared to the normal epithelium [21] Blanc et al.
O mecanismo de protecao luteal exercido pelo IFN-[tau] sobre o CL esta relacionado com a estabilizacao de genes envolvidos com a sobrevivencia do CL, como o BCL2-like 1, serine/ threonine kinase (AKT), e X-linked inhibitor of apoptosis (XIAP) e diminuicao na concentracao do RNAm do receptor de PGF (PTGFR).