XIAP

Also found in: Dictionary, Financial, Acronyms, Wikipedia.

Related to XIAP: Inhibitor of Apoptosis Protein 1

XIAP

A gene on chromosome Xq25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. XIAP acts by binding to tumour necrosis-factor receptor-associated factors TRAF1 and TRAF2, inhibits apoptosis induced by menadione—a free radical inducer and IL1-beta converting enzyme—and inhibits cell-death proteases caspase-3 and caspase-7.

Molecular pathology
XIAP mutations cause X-linked lymphoproliferative syndrome.

Mentioned in ?

References in periodicals archive ?

To calculate which protein is more likely to end up with the NO 'hot potato,' caspases or XIAP, the researchers created a new version of the Nernst equation - a 19th century mathematical equation taught in every general chemistry class.

New clues about cause of brain cell death in Parkinson's, Alzheimer's

The scientists have already developed a second generation of XIAP inhibitors that last longer in the body and have other improved biochemical properties.

Compounds trigger tumor-cell suicide

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis cell survival and proliferation.

Cancer de prostata y apoptosis

After blocking endogenous peroxidase activity and nonspecific antigen binding, the tissue sections were incubated with monoclonal antibodies against p53, AIF, XIAP, CC3 (Asp175), anti-histone H2AX, Bcl2, M30, and Ki-67 overnight in a moist chamber.

Mechanism of villous atrophy in celiac disease: role of apoptosis and epithelial regeneration

2] regulate expression of Bcl-xL but not Bcl-2 and XIAP in human osteoblastic MG-63 cells

Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation

The XIAP gene is known to be important for programmed cell death and the proinflammatory response.

Developing genome and exome sequencing for candidate gene identification in inherited disorders: an integrated technical and bioinformatics approach

The membranes were incubated with primary antibodies against Bax, Bad, Bc1-2, IGF1R, IGFBP3, P[beta]K, XIAP, caspases, Cyclin D (1: 2000) and GSK-3[beta], p-GSK-3[beta], IKKa, IKKI3, NFkB, p-Akt, Akt (1:1000) in Tris-buffered saline.

Effect of diallyl disulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis