and the Indian-subcontinent: effective prevention strategies needed.
Bedaquiline plus delamanid for XDR tuberculosis
. Lancet Infect Dis.
"The widespread emergence of XDR tuberculosis
could lead to virtually untreatable tuberculosis," wrote the authors of one study, led by Alimuddin Zumla, director of the Centre for Infectious Diseases and International Health at University College London Medical School .
Tissues taken for histopathology should also be sent for AFB stain and AFB culture and sensitivity, to rule out MDR and XDR tuberculosis
is resistant to at least rifampicin, isoniazid, and one or more of the second-line antituberculosis drugs.
- Implications for global public health.
Persons infected with MDR or XDR tuberculosis
have poor clinical outcome and over 60% more likely to die during treatment.
A surge of MDR and XDR tuberculosis
in France among patients born in the Former Soviet Union.
A large study done in Pakistan over 17.5 years has reported 22 cases of XDR tuberculosis
, the first case being reported in 1998.
In particular, a 30-year-old male from Moldova and a 24-year-old female patient from Ukraine underwent very prolonged hospitalizations due to XDR tuberculosis
. The first patient, with tubercular disease known since six years, developed XDR M.
The global threat of XDR tuberculosis
has great importance for public health and TB control.
: implications for global public health.