XCR1


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XCR1

A gene on chromosome 3p21.3-p21.1 that encodes a G protein-coupled receptor for chemokines SCYC1 and SCYC2, which transduces signals by increasing intracellular Ca2+ levels.
References in periodicals archive ?
The N-terminal is rich in tyrosine and acidic amino acids, and its coding gene is located on 3p21 chromosome along with groups of other chemokine coding genes such as CCR1, CCR2, CCR3, and XCR1 [6].
Tang et al., "XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow," American Journal of Clinical Pathology, vol.
The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3, CXCL13, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.1- to 9.25-fold (Supplementary Table S4, Figure 4), while 46 cytokine receptors (CSF3R, CXCR7, IL-17RA, IL-18R1, IL-1R1, IL-1R2, IL-20RA, IL-21R, IL-2RG, IL-4I1, IL-5RA, IL-7R, IL-9R, LILRB3, TGFBR1, TLR1, TLR15, TLR21, TLR5, TLR6, TLR7, TNFRSF13B, TNFRSF13C, TNFRSF1B, TRAT1, XCR1, etc.) were also significantly upregulated by 2.04- to 10.16-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figure 5).
Similarly, the expression of 18 cytokine genes (IL-7, IL-10, TNFAIP8, SPP2, TNFAIP3, IFNB, CCL19, TNFAIP8L1, IL-16, CNTF, CXCL13, TNFAIP8L3, TNFSF13B, IL-34, TGFB1, TNFAIP2, CCL3, and ADIPOQ) and 39 cytokine receptor genes (CXCR7, CSF2RA, IL-1RL1, I-L1R2, IL-17RA, IFNAR1, IL-18RAP, IL-31RA, IL-9R, IL-18R1, IL-20RB, IL-21R, IL-2RG, IL-20RA, IL-4I1, LILRB1, TLR1, IL-17REL, LILRB5, TGFBR1, TLR6, TNFRSF13B, XCR1, TLR7, TNFRSF13C, TLR15 etc.) was also markedly upregulated by 2.03- to 8.41-fold and 2.08- to 9.12-fold, respectively, in chicken line 7.2 with p < 0.01 and fold [greater than or equal to] 2 (Supplementary Table S4, Figures 4 and 5).
Hartung et al.,"Superior antigen cross-presentation and XCR1 expression define human [CD11c.sup.+][CD141.sup.+] cells as homologues of mouse [CD8.sup.+] dendritic cells," Journal of Experimental Medicine, vol.207, no.6, pp.1273-1281, 2010.
The limbs connect to the XCR1 riser via High Country's new Vibra Damp limb pockets, which use the new Ball and Socket Limb Bolt Mounts and new S-D Tech Pads to dampen vibration in the pockets.
The linkage between [CD8.sup.+] DC and [CD103.sup.+] DC was further strengthened by the reports showing unique common expression of XCR1, a chemokine receptor, by these DC subsets [8, 9].
The expressions of CCR4, CCR7, and XCR1 ligands in the medullary epithelial cells were modulated by Aire [68, 69].