XBP1

XBP1

A gene on chromosome 22q12.1 that encodes a bZIP protein transcription factor, which regulates MHC class-II genes by binding to a promoter element or X box.
 
Molecular pathology
XBP1 binds to a T-cell leukaemia virus type-1 promoter, and may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
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The balance between adaptive and apoptotic unfolded protein responses regulates [beta]-cell death under ER stress conditions through XBP1, CHOP and JNK.
Finally, ATF6 is activated in the Golgi complex through proteolytic cleavage and translocates to nucleus where it cooperates with XBP1 in upregulation of chaperones and ERAD-related genes [43].
16) Had Takashi allowed me to employ multicopy suppressor screening, I might have been able to identify Hac1p (as Peter did) but Hiderou Yoshida and I would never have identified ATF6 and XBP1, two critical mammalian UPR-specific transcription factors, because multicopy suppressor screening works only for yeast genes.
We have recently reported that unabated ER stress, a consequence of genetic deletion of X-box binding protein-1 (XBP1), in intestinal epithelial cells (IECs) leads to intestinal inflammation reminiscent of inflammatory bowel disease (IBD), and polymorphisms in XBP1 were associated with Crohn s disease and ulcerative colitis.
Glimcher's team found that the gene, XBP1, is especially active in triple negative breast cancer, particularly in the progression of malignant cells and their resurgence after treatment.
Scientists at the University of Galway have revealed how cancerous cells survive and become resistant to treatment by emitting a survival factor called XBP1.
Among the genes that are transcriptionally regulated by ATF4, ATF6, and XBP1, CHOP10 is one of the mostly expressed inducible genes during ER stress (Oyadomari and Mori 2004).
ISTANBUL, Feb 17, 2011 (TUR) -- A Turkish molecular biologist has said his research had shown that facilitating the production of a protein called XBP1 could lower blood sugar back to normal in lab rats both with Type 2 and Type 1 diabetes.
The researchers said that if the gene, called XBP1, is poorly functioning, it causes the risk of bipolar disorder to increase by 4.
The pre-clinical study, conducted by researchers at Dana-Farber Cancer Institute in collaboration with MannKind Corporation (Nasdaq: MNKD), confirm that blocking the XBP1 arm of the unfolded protein response with MannKind's novel, first-in-class IRE1 RNase domain inhibitor, MKC-3946, alone or in combination with bortezomib or 17AAG, inhibited growth in multiple myeloma cells, while leaving normal cells intact.
Together with XBP1, activated ATF6 subsequently translocates into the nucleus and regulates transcription of target genes to restore ER function (Li et al.