XBP1

XBP1

A gene on chromosome 22q12.1 that encodes a bZIP protein transcription factor, which regulates MHC class-II genes by binding to a promoter element or X box.
 
Molecular pathology
XBP1 binds to a T-cell leukaemia virus type-1 promoter, and may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
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We have recently reported that unabated ER stress, a consequence of genetic deletion of X-box binding protein-1 (XBP1), in intestinal epithelial cells (IECs) leads to intestinal inflammation reminiscent of inflammatory bowel disease (IBD), and polymorphisms in XBP1 were associated with Crohn s disease and ulcerative colitis.
Glimcher's team found that the gene, XBP1, is especially active in triple negative breast cancer, particularly in the progression of malignant cells and their resurgence after treatment.
Scientists at the University of Galway have revealed how cancerous cells survive and become resistant to treatment by emitting a survival factor called XBP1.
Among the genes that are transcriptionally regulated by ATF4, ATF6, and XBP1, CHOP10 is one of the mostly expressed inducible genes during ER stress (Oyadomari and Mori 2004).
Mutations of the XBP1 gene for example, directly affect the endoplasmatic reticulum's unfolded protein response pathway.
ISTANBUL, Feb 17, 2011 (TUR) -- A Turkish molecular biologist has said his research had shown that facilitating the production of a protein called XBP1 could lower blood sugar back to normal in lab rats both with Type 2 and Type 1 diabetes.
The researchers said that if the gene, called XBP1, is poorly functioning, it causes the risk of bipolar disorder to increase by 4.
The pre-clinical study, conducted by researchers at Dana-Farber Cancer Institute in collaboration with MannKind Corporation (Nasdaq: MNKD), confirm that blocking the XBP1 arm of the unfolded protein response with MannKind's novel, first-in-class IRE1 RNase domain inhibitor, MKC-3946, alone or in combination with bortezomib or 17AAG, inhibited growth in multiple myeloma cells, while leaving normal cells intact.
What we found is, in conditions of obesity, XBP1 cannot go to the nucleus and there is a severe defect in the up-regulation of chaperones.
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Harvard Medical School based investigators and international team pinpoint the role of the XBP1 gene in the development of Crohn's and colitis, digestive diseases affecting over 1.