XBP1

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XBP1

A gene on chromosome 22q12.1 that encodes a bZIP protein transcription factor, which regulates MHC class-II genes by binding to a promoter element or X box.
 
Molecular pathology
XBP1 binds to a T-cell leukaemia virus type-1 promoter, and may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
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Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.
Together, the findings suggest that either increasing p38 MAPK activity -- despite its being an inflammatory signal -- or increasing XBP-1 activity by other means could represent new therapeutic options for diabetes.
Hu et al [62] reported that XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 in zebrafish embryonic cell line.
XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line.
Instead of travelling to the cell nucleus and turning on genes called chaperones, necessary for proper ER function, XBP-1 becomes stranded.
Researchers at Dana-Farber Cancer Institute in collaboration with MannKind Corporation (Nasdaq:MNKD) generated results confirming that targeting the unfolded protein response (UPR) through the XBP-1 pathway impacts the survival of myeloma cells, suggesting a novel therapeutic strategy in multiple myeloma.
Targeting the Unfolded Protein Response (UPR) Transcription Factor XBP-1 to Treat Parkinson's Disease
Results from nonclinical studies show that the IRE-1 compound inhibits growth of tumor cells by selectively targeting and inhibiting the key signaling process that regulates protein folding and facilitates cell death, known as the IRE-1 and XBP-1 (X-box binding protein-1) pathway.
Instead of traveling to the cell nucleus and turning on genes called chaperones, necessary for proper ER function, XBP-1 becomes stranded.
Glimcher, MD Is the Transcription Factor XBP-1 a Critical Target for Proteasome Inhibitors in Multiple Myeloma?
This suggests that approaches aimed at increasing XBP-1s activity may benefit patients with either type of diabetes.