AIP

(redirected from XAP2)
Also found in: Acronyms.

AIP

(1) A 330 residue protein that helps stabilise the AIP-hsp90-AhR complex and protects the AhR receptor from ubiquitination under heat-stress conditions; AIP may also play a role in regulating the rate of AhR turnover by delaying AhR nuclear translocation after ligand binding.
(2) A gene on chromosome 11q13.3 that encodes a receptor for aryl hydrocarbons and a ligand-activated transcription factor. It resides in the cytoplasm as part of a multiprotein complex and is transported to the nucleus once it binds with a ligand. AIP regulates the expression of many xenobiotic metabolising enzymes; it binds specifically to and inhibits the activity of hepatitis B virus.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

AIP

Acute intermittent porphyria
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Dioxins bind to the aryl hydrocarbon receptor (AhR), which, after dissociating from its complex of chaperone proteins in the cytoplasm (including HSP90 and XAP2) translocates to the nucleus.
This implementation provides users with a 16-bit RISC processor core called XAP2 and a configurable coprocessor called APE2.
In the last few years, additional components of the AhR complex have been identified, including the AhR repressor, AhR-interacting protein (also known as XAP2), Rb protein, receptor-interacting protein 140, SRC-1, p23, and the RelA NF-[kappa]B subunit (Carlson and Perdew 2002; Kumar and Perdew 1999; Mimura et al.