The Crystal Farm family of products with its integrated crystal incubation and imaging capabilities complements Bruker AXS's line of X-ray crystallography
products for structural proteomics applications.
As an initial step in the drug discovery process, we purified the BPL from golden staph, grew crystals of the enzyme and determined its 3D structure using X-ray crystallography
In Wilson's laboratory, postdoctoral fellow Rui Xu, the study's first author, along with Staff Scientist Xueyong Zhu and Research Assistant Wenli Yu, performed X-ray crystallography
studies of the Sh2 HA protein bound to several avian- and human-type receptors.
Another essential development in the science of x-ray crystallography
was the invention by the French mathematician Fourier of what has come to be known as modern harmonic analysis, or Fourier theory.
Although it's been 45 years since the first protein structure was determined using x-ray crystallography
, growing viable crystals, especially from complex large molecules, remains the most troublesome step in the process.
Although we cannot state with certainty the mechanism by which Cd(II), Fe(II), or Pb(II) [three metals that have divergent coordination chemistries and different ligand preferences (Lippard and Berg 1994)] inactivates Ape1, both X-ray crystallography
and NMR spectroscopy studies found that lead can occupy two potential divalent metal binding site within the Ape I active site (Beernink et al 2001; Lowry et al.
Their experience, combined with our expertise in X-ray crystallography
, represents a highly synergistic and focused alliance.
The role of the hydroxyl group of Tyr6 in the catalytic mechanism of isoenzyme 3-3 of rat glutathione S-transferase was examined by x-ray crystallography
and site-specific replacement of the residue with phenylalanine and evaluation of the catalytic properties of the mutant enzyme.
We understand how biological molecules such as proteins and DNA do their jobs because we can use X-ray crystallography
to study their atomic structure, and we can design and analyse futuristic smart materials that make modern technological devices and stunning new buildings possible.
Second, the structural organization of cargo-receptor complexes will be defined for a hetero-oligomeric, mechanosensitive model complex involved in muscle homeostasis using a combination of cryo-EM and X-ray crystallography
Researchers have solved the challenging crystal structure of the leptin-binding domain of the obesity receptor using state of the art X-ray crystallography
, helping them to work out how to block or stimulate the receptor.
The key benefit of this platform for the selection of target-specific strategies is its versatility, combining biochemical and biophysical techniques including nuclear magnetic resonance (NMR), surface plasmon resonance (SPR) and X-ray crystallography
, Evotec added.