X-linked recessive


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X-linked recessive

Genetics adjective Referring to a mode of inheritance, in which a gene on the X chromosome requires one copy for phenotypic expression in ♂, but 2 copies for expression in ♀; with the gene only on the X chromosome, ♀ are carriers; ♂ get the disease. Cf Autosomal dominant, Autosomal recessive.

X-linked recessive

Pertaining to a gene situated on an X chromosome which is expressed if the chromosome is carried on both X chromosomes in a female (which is necessarily rare). In males, however, the Y chromosome carries little or no genetic material and does not contain the normal ALLELE, so the gene on the X chromosome will always manifest itself. An X-linked recessive condition will thus usually occur only in males (who have one X and one Y chromosome) but cannot be transmitted by a father to his son because the son receives only the Y chromosome. The characteristic is, however, transmitted via the daughters, who are carriers. Their sons have a 50/50 chance of acquiring the X chromosome and manifesting the characteristic.
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AdRP represents 15-20% of all cases of RP, arRP comprises 20-25% of cases and the X-linked recessive type makes up 10-15% of cases.
Retinitis pigmentosa genes implicated in South Asian populations: a systematic review
However, based on pedigree analysis, X-linked recessive inheritance is most likely, which is similar to the recent report of clustering in a family.
Neonatal Stridor in Familial Congenital Laryngeal Paralysis (Plott Syndrome): A Case Study in an Omani Family
G2P-hex also effectively describes why dominant mode does not skip any generation (because all kinds of parent unions involving at least one affected allele result in affected offspring) whereas recessive mode tend to skip generations (because of possibility of producing all normal offspring though carriers of disease in 0-1 and 0-2 parent unions in autosomal recessive and F1-M0 union in X-linked recessive modes).
Genotype and Phenotype Probabilities by Ternary Code based Line-dot Method and Polygonal Illustrations
Mutations in the dystrophin (Duchenne muscular dystrophy [ DMD ]) gene, which encodes a protein connecting the cytoskeleton of muscle fibers, result in X-linked recessive dystrophinopathy, including DMD and Becker muscular dystrophy (BMD).
A De novo Mutation in Dystrophin Causing Muscular Dystrophy in a Female Patient
He published work in the New England Journal of Medicine focused on X-linked recessive mutations and male infertility.
Update: a distinguished Board of Editors
Osteopetrosis can be inherited in an AD, autosomal recessive (AR), or X-linked recessive (XR) manner (2).
A girl with bone sclerosis and fracture
Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) also known as "favism" is an X-linked recessive genetic condition that predisposes to hemolysis1 and resultant jaundice in response to triggers, such as hypoxia, certain foods, illness and medication2.
EMPLOYMENT OF G6PD DEFICIENT PATIENT IN HIGH ALTITUDE AREA - A CASE STUDY
2) Certain anatomical abnormalities of the urinary tract and specific drugs can increase the chances of stone formation; and, finally, there are several inherited disorders predisposing individuals metabolically to nephrolithiasis such as autosomal recessive cystinuria and X-linked recessive Lesch-Nyhan syndrome.
Recurrent urinary tract infections in a 48-year-old female
The disease has an X-linked recessive pattern of inheritance and results from IKBKG gene-NF-kB signaling abnormality.
Malignant infantile osteopetrosis with cleft lip--a case report
It is an X-linked recessive disorder, which is more prevalent in males than in females.
Market Report, "Global Hemophilia A Market 2015-2019 - Industry Analysis", published
1) The inheritance can be autosomal dominant, autosomal recessive or X-linked recessive.
Retinitis pigmentosa
Juvenile X-linked retinoschisis is an inherited disorder transmitted as an X-linked recessive trait and thus affecting males almost exclusively.
Is it normal? Peripheral retinal findings--Part 2

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