X-linked lymphoproliferative syndrome

(redirected from X-linked lymphoproliferative disease)

X-linked lymphoproliferative syndrome

an X-linked recessive immunodeficiency and lymphoproliferative disease caused by mutation in the SH2 domain protein 1A gene (SH2D1A) on Xq; characterized by defective cellular or humoral immune response to Epstein-Barr virus; manifestations include fulminant infectious mononucleosis, B-cell malignancies, and hypogammaglobulinemia.

X-linked lymphoproliferative syndrome

an X-linked recessive immunodeficiency and lymphoproliferative disease caused by mutation in the SH2 domain protein 1A gene (SH2D1A) on Xq; characterized by defective cellular or humoral immune response to Epstein-Barr virus; manifestations include fulminant infectious mononucleosis, B-cell malignancies, and hypogammaglobulinemia.
Farlex Partner Medical Dictionary © Farlex 2012

X-link·ed lym·pho·pro·lif·er·a·tive syn·drome

(lingkt lim'fō-prō-lif'ĕr-ă-tiv sin'drōm)
An X-linked recessive immunodeficiency and lymphoproliferative disease caused by mutation in the SH2 domain protein 1A gene (SH2D1A) on Xq; characterized by defective cellular or humoral immune response to Epstein-Barr virus; manifestations include fulminant infectious mononucleosis, B-cell malignancies, and hypogammaglobulinemia.
Synonym(s): Duncan disease.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immunodeficiency that leads to unique vulnerability to the Epstein-Barr virus (EBV).
Veillette, "Molecular and immunological basis of X-linked lymphoproliferative disease," Immunological Reviews, vol.
Khan, "Diffuse CNS vasculopathy with chronic EpsteinBarr virus infection in X-linked lymphoproliferative disease," American Journal of Neuroradiology, vol.
X-linked lymphoproliferative disease is a rare immunodeficiency disease that is characterized by a prediction for fatal or near-fatal EBV-induced infectious mononucleosis in childhood, subsequent hypogammaglobulinemia, and a markedly increased risk of lymphoma or other lymphoproliferative diseases (24).
After suffering kidney failure and undergoing a heart operation, Jamie was diagnosed with X-linked lymphoproliferative disease at the age of three - believed to be one of only 300 people in the world with the condition.
One of his diseases, X-linked lymphoproliferative disease, XLP, is so rare there are only 100 other known cases in the world.
Tokyo, Japan, Sept 20, 2006 - (JCN) - GNI and its Chinese affiliate Shanghai Genomics announced September 15 that they have identified an important regulator and its associated signaling cascade in X-linked lymphoproliferative disease (XLP), a human immunological disorder.
They have X-linked lymphoproliferative disease which usually kills before sufferers reach their teens.
Joshua Hartley, aged 13, and his brothers Nathan, 12, Daniel, nine, and Luke, five, were diagnosed with the extremely rare genetic defect known as X-linked Lymphoproliferative disease, or Duncan's syndrome, in November 2003.
The Hartleys from Romsey, Hants, were told in November their four sons have X-linked lymphoproliferative disease, known as Duncan's syndrome.
Joshua, 12, Nathan, 10, Dan-iel, eight, and Luke, four, have X-linked lymphoproliferative disease.
The brothers have X-linked lymphoproliferative disease (XLP) - also known as Duncan's Syndrome.

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