Bid: BH3 interacting domain death agonist; cIAP: cellular inhibitor of apoptosis; CJ: cisjasmonic acid; 2DG: 2-deoxy-D-glucose; Glc: glucose; J7: methyl 5-chloro-4,5- didehydrojasmonate; JA: jasmonic acid; NSCLC: nonsmall-cell lung carcinoma; Pgp: P-glycoprotein; MDDHJ: methyl 4,5-didehydro- jasmonate; MDR: multidrug resistance; MMP-14: matrix metalloprotease 14; PARP: poly (ADP-ribose) polymerase; PCNA: proliferating cell nuclear antigen; PTPC: permeabilitytransition pore complex; ROS: reactive oxygen species; S100P: protein SP100; TBrJA: 5,7,9,10-tetrabromo jasmonate; TNFR1: tumor-necrosis factor receptor-1; TRAIL: tumor necrosis factor-(TNF-) related apoptosis-inducing ligand; XIAP: X-linked inhibitor of apoptosis
X-linked inhibitor of apoptosis
protein (XIAP) was quantified by Western blotting analysis.
Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis
downregulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response.
Aegera has taken this technology to the clinic with an antisense therapeutic, AEG35156, targeting just one of their IAPs named the X-linked inhibitor of apoptosis
(XIAP) protein, a target which inhibits apoptosis using duel mechanisms.
Significant apoptosis was detected in embryonic heart at the time of outflow tract shortening , and inhibition of apoptosis using the pan-caspase inhibitor zVAD-fmkor adenoviral mediated expression of X-linked inhibitor of apoptosis
protein resulted in excessive outflow tract above the base of the ventricles , indicating that apoptosis is required for morphogenesis of the outflow tract myocardial tissue.