X-linked


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X-linked

 [eks´lingkt]
transmitted by genes on the X chromosome; see also X-linked gene.
The probabilities of male relatives being affected and female relatives being carriers of an X-linked recessive disorder. All the daughters of an affected male are obligate carriers. From Mueller and Young, 2001.

X-linked

(linkt),
Pertaining to genes borne on the X chromosome. Avoid confusing this word with sex-linked.

X-linked

(eks´linkt) transmitted by genes on the X chromosome; sex-linked.

X-linked

(ĕks′lĭngkt′)
adj.
Of, relating to, or characterized by genes located on the X chromosome.

X-linked

[eks′ lingkt]
pertaining to genes or to the characteristics or conditions they transmit that are carried on the X chromosome. Compare Y-linked. See also sex-linked disorder. X linkage, n.

X-linked

Sex linked Genetics adjective Referring to a mode of transmission in which a trait or gene is linked to the X chromosome and generally expressed only in males. See Gene, Mutation, Sex chromosome.

X-link·ed

(lingkt)
Pertaining to genes borne on the X chromosome. Commonly but erroneously used synonymously with sex-linked, which would also comprise Y-linked traits.

X-linked

Pertaining to genes, or to the effect of genes, situated on the X CHROMOSOME. X-linked disorders are those caused by mutated genes on the X chromosome. They include AGAMMAGLOBULINAEMIA, ALBINISM, ALPORT SYNDROME, Charcot-Marie-Tooth peroneal muscular atrophy, COLOUR BLINDNESS, DIABETES INSIPIDUS, ectodermal dysplasia, glucose-6-phosphate dehydrogenase deficiency, FABRY DISEASE, glycogen storage disease VIII, gonadal dysgenesis, HAEMOPHILIA A, one form of HYDROCEPHALUS, HYPOPHOSPHATAEMIA, ICHTHYOSIS, TURNER'S SYNDROME, one form of mental retardation, Becker and Duchesse MUSCULAR DYSTROPHY, one form of RETINITIS PIGMENTOSA and the TESTICULAR FEMINIZATION SYNDROME.

X-linked

Located on the X chromosome, one of the sex chromosomes. X-linked genes follow a characteristic pattern of inheritance from one generation to the next.

X-link·ed

(lingkt)
Pertaining to genes borne on the X chromosome.

X-linked

traits transmitted by genes on the X chromosome; sex-linked; the categories are X-linked dominant, X-linked recessive.

X-linked agammaglobinemia
see Bruton's agammaglobulinemia.
X-linked trait
sex-linked, e.g. coat color in cats, hemophilia.
References in periodicals archive ?
X-linked cardioskeletal myopathy and neutropenia (Barth syndrome) (MIM 302060).
Fabry's disease is an X-linked recessive disorder of glycosphingolipid catabolism caused by a deficiency of the lysosomal enzyme [alpha]-galactosidase A as a consequence of one or more than four dozen mutations.
Kinetics of transfused neutrophils in peripheral blood and BAL fluid of a patient with variant X-linked chronic granulomatous disease.
However, rare features included no spinal cord involvement and no family history of males with spinal cord disease or AMN (since this disease is X-linked disorder), though 5% may occur by de novo mutation (7).
A form of X-linked mental retardation with marfanoid habitus.
X-linked hypophosphataemic rickets (XLH), which is the commonest of the hypophosphataemic syndromes, is caused by inactivating mutations in the PHEX gene, which result in elevations of FGF23.
X-linked HED is caused by mutations in the EDA gene located in region Xq12-q13.
Unlike the case with X-linked Alport syndrome, which in affected males is nearly always a progressive disease leading to end-stage renal disease, the phenotypic expression of autosomally transmitted Alport syndrome is quite variable, ranging from benign urinary abnormalities to progressive nephropathy leading to end-stage renal disease.
Sex selection for the prevention of X-linked disorders is generally regarded as morally acceptable.
At first they thought he was wrestling with leukemia, but later he was diagnosed with a rare immune disorder called X-linked lymphoproliferative that affects fewer than one in 1 million males.
Amelogenesis imperfecta (AI) is defined as a rare developmental hereditary abnormality caused by autosomal or X-linked dominant or recessive genes.
In the absence of a family history of X-linked mixed deafness syndrome, surgeons may have difficulty determining if a patient is at risk preoperatively.