XBP1

(redirected from X-box-binding protein 1)

XBP1

A gene on chromosome 22q12.1 that encodes a bZIP protein transcription factor, which regulates MHC class-II genes by binding to a promoter element or X box.
 
Molecular pathology
XBP1 binds to a T-cell leukaemia virus type-1 promoter, and may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
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References in periodicals archive ?
Activated IRE1 induces the splicing of XBP1 (X-box-binding protein 1) mRNA by cleaving off its intron [12].
In a recent study, we found that treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of IRE1 and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in the PFC attenuated social behavioral deficits caused by tunicamycin treatment [15].