Isotopic response described in 1955 by Wyburn-Mason
, later characterized by Wolf and Wolf, is the occurrence of a new dermatological disease at the site of a healed or pre-existing previous dermatological disease, and is well reported with a second disease occurring in herpes zoster scars.8
One of our founders, Roger Wyburn-Mason, MD, PhD (deceased), often wrote of this folly, stating that one of his medical students invented double-blind studies as a joke, and thereafter everyone was somewhat flabbergasted when the joke was taken seriously.
Wyburn-Mason often wrote that perhaps double-blind studies can discriminate between two similar NSAIDs, showing that one was slightly better than another; but beyond that, such studies could not substitute for intelligent clinical analysis and comparisons.
Differential diagnosis of Wyburn-Mason syndrome and Sturge-Weber syndrome was considered which were ruled out on history and examination.
PHACE syndrome has to be differentiated from some other neurocutaneous syndromes like Wyburn-Mason syndrome and Sturge-Weber syndrome.