Working Formulation

Working Formulation

A classification of non-Hodgkin lymphomas which was created in 1982 to improve communication among various lymphoma experts, which had been difficult due to the plethora of classifications extant up to that point. The Working Formulation was easily applied by pathologists and relatively predictive of the lymphoma’s future behaviour, based on its stratification of lymphomas into low, intermediate, and high grades. While it has been retired by bench pathologists, it may still be used by agencies that compile lymphoma statistics.

Despite the Working Formulation’s acceptance and ease of application by pathologists, it had enough fatal flaws that it was replaced by the Revised European American classification in the 1990s, which tried to apply immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas.

Working Formulation
Low Grade
• Malignant Lymphoma—small lymphocytic (chronic lymphocytic leukaemi(1)).
• Malignant Lymphoma—follicular, predominantly small cleaved cell.
• Malignant Lymphoma—follicular, mixed (small cleaved and large cell).

Intermediate grade
• Malignant Lymphoma—follicular, predominantly large cell.
• Malignant Lymphoma—diffuse, small cleaved cell.
• Malignant Lymphoma—diffuse, mixed small and large cell.
• Malignant Lymphoma—diffuse, large cell.

High grade
• Malignant Lymphoma—large cell, immunoblastic.
• Malignant Lymphoma—lymphoblastic.
• Malignant Lymphoma—small non-cleaved cells (Burkitt's lymphom(1)).

Miscellaneous
• Composite
• Mycosis fungoides
• Histiocytic
• Extramedullary plasmacytoma
• Unclassifiable
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
However, the 2007 working formulation also states that "A diagnosis of acute rejection is based exclusively on the presence of perivascular and interstitial mononuclear cell infiltrates." (3(p1230)) This statement is the result of controversy among pathologists as to the significance of airway inflammation, distinguishing infection from acute rejection, and separating bronchioles from cartilage containing airways.
A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Lung Rejection Study Group.
The lymphomas were classified under NHLs and HL accordingly using the "working formulation for clinical Usage" (1982) and the "Rye Classification" (1966).
Analysis of histologic types using working formulation for clinical usage showed 56 cases belonged to clinically aggressive intermediate grade with incidence(80%), 9 cases (12.8%) in low grade and 5cses (7.4%) in high grade subtypes.
Burke et al., "The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011)," Journal of Heart and Lung Transplantation, vol.
At the time of diagnosis, the tumor is usually low- or intermediate-grade by the Working Formulation, and the patient is found to have Ann Arbor stage I or II disease.[1] The most common types are follicular small cleaved, follicular mixed, and diffuse large cell lymphomas.[2] Tumors of small lymphocytes are generally slow to progress and have a favorable long-term prognosis, with 52% to 83% survival at 5 years.[1] Large cell variants are rapidly progressive and have a poor outcome/and those with Ann Arbor stage III or IV disease are more resistant to treatment.
The lesion can be classified as diffuse mixed small and large cell lymphoma by the Working Formulation. Since all the neoplastic cells appear large, and tumors are usually classified on the basis of the neoplastic cells, the more appropriate designation may be diffuse large B-cell lymphoma, as in the World Health Organization's recently released classification and the Revised European-American Lymphoma Classification.[17]
GS had a distinguishing language in its new terminology comprehensible to those initiated into its working formulations.
Occupational exposure to EBDCs entails exposures to the parent compound(s) plus other ingredients of the working formulations used in agriculture, as well as to endogenously formed ETU and other metabolites, and is not identical to environmental exposure to ETU per se.
Therefore, by far the majority of working formulations are carbon black filled.