Working Formulation

Working Formulation

A classification of non-Hodgkin lymphomas which was created in 1982 to improve communication among various lymphoma experts, which had been difficult due to the plethora of classifications extant up to that point. The Working Formulation was easily applied by pathologists and relatively predictive of the lymphoma’s future behaviour, based on its stratification of lymphomas into low, intermediate, and high grades. While it has been retired by bench pathologists, it may still be used by agencies that compile lymphoma statistics.

Despite the Working Formulation’s acceptance and ease of application by pathologists, it had enough fatal flaws that it was replaced by the Revised European American classification in the 1990s, which tried to apply immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas.

Working Formulation
Low Grade
• Malignant Lymphoma—small lymphocytic (chronic lymphocytic leukaemi(1)).
• Malignant Lymphoma—follicular, predominantly small cleaved cell.
• Malignant Lymphoma—follicular, mixed (small cleaved and large cell).

Intermediate grade
• Malignant Lymphoma—follicular, predominantly large cell.
• Malignant Lymphoma—diffuse, small cleaved cell.
• Malignant Lymphoma—diffuse, mixed small and large cell.
• Malignant Lymphoma—diffuse, large cell.

High grade
• Malignant Lymphoma—large cell, immunoblastic.
• Malignant Lymphoma—lymphoblastic.
• Malignant Lymphoma—small non-cleaved cells (Burkitt's lymphom(1)).

• Composite
• Mycosis fungoides
• Histiocytic
• Extramedullary plasmacytoma
• Unclassifiable
References in periodicals archive ?
According to the 1990 Working Formulation for the Standardization of Nomenclature in the Diagnosis of Heart and Lung Rejection: Lung Rejection Study Group report, "acute rejection is characterized by both perivascular mononuclear infiltrates and a lymphocytic bronchitis/bronchiolitis.
However, the 2007 working formulation also states that "A diagnosis of acute rejection is based exclusively on the presence of perivascular and interstitial mononuclear cell infiltrates.
In a Indian study of fifty three cases of NHLs of detailed morphological assessment and classified using the international working formulation reported diffuse large cell lymphoma and small lymphocytic lymphoma commonest types.
Analysis of histologic types using working formulation for clinical usage showed 56 cases belonged to clinically aggressive intermediate grade with incidence(80%), 9 cases (12.
Este sistema de clasificacion se diferencia de otras clasificaciones como la de Kiel y Working Formulation, que consideran unicamente los criterios morfologicos, como el crecimiento dentro del linfonodulo (nodular o difuso), y el tamano de las celulas neoplasicas (pequenas, grandes o mixtas) (Parodi, 2001).
At the time of diagnosis, the tumor is usually low- or intermediate-grade by the Working Formulation, and the patient is found to have Ann Arbor stage I or II disease.
GS had a distinguishing language in its new terminology comprehensible to those initiated into its working formulations.
Therefore, by far the majority of working formulations are carbon black filled.