Wolman disease

(redirected from Wolman's)

cho·les·ter·ol es·ter stor·age dis·ease

[MIM*278000]
a lipidosis caused by a deficiency of lysosomal acid lipase activity resulting in widespread accumulation of cholesterol esters and triglycerides in viscera with xanthomatosis, adrenal calcification, hepatosplenomegaly, foam cells in bone marrow and other tissues, and vacuolated lymphocytes in peripheral blood; autosomal recessive inheritance, caused by mutation in the lysosomal acid lipase gene (LIPA) on chromosome 10q.
Farlex Partner Medical Dictionary © Farlex 2012

Wolman disease

(wôl′mən)
n.
A lysosomal storage disease caused by deficiency of an enzyme that breaks down lipids, characterized by the accumulation of cholesterol esters and triglycerides in the tissues and resulting in enlargement of the liver and spleen, abdominal distension, steatorrhea, cachexia, and usually death in infancy.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cho·les·ter·ol es·ter stor·age dis·ease

(kŏ-les'tĕr-ol es'tĕr stōr'ăj di-zēz')
A lipidosis caused by a deficiency of lysosomal acid lipase activity resulting in widespread accumulation of cholesterol esters and triglycerides in viscera with xanthomatosis, adrenal calcification, hepatosplenomegaly, foam cells in bone marrow and other tissues, and vacuolated lymphocytes in peripheral blood; autosomal recessive inheritance, caused by mutation in the lysosomal and lipase gene (LIPA) on chromosome 10q.
Synonym(s): Wolman disease, Wolman xanthomatosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Wolman,

Moske, Israeli neuropathologist, 1914–.
Wolman disease - lipidosis caused by deficiency of liposomal acid lipase activity. Synonym(s): cholesterol ester storage disease
Wolman xanthomatosis
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Ala, "Wolman's disease and cholesteryl ester storage disorder: the phenotypic spectrum of lysosomal acid lipase deficiency," The Lancet Gastroenterology and Hepatology, vol.
Ultrasound appearance of bowel wall in wolman's disease.
( Right) Baron Wolman's iconic photograph of Jimi Hendrix is also on display at the exhibition.
This award is one of AWWA's highest honors and is presented annually to recognize those whose careers in the water works industry exemplify vision, creativity and excellent professional performance characteristic of Abel Wolman's long and productive career.
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Johns Hopkins' Abel Wolman, pioneer of drinking-water chlorination, argued before the Senate that it was "not fair" to require controls on pollution if the "investment return did not compare favorably with the return on other capital projects." To the modern scientist, aware of the strides made in recent decades under federal regulation, Wolman's view represents a capitulation to a false economics and a failure of the imagination.
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Ultimately, "Waltz with Bashir" is Ari Wolman's statement on the futility of all wars and what it does to those who have to fight them.
While Wolman's research is well documented and the book has extensive notes, what makes it enjoyable as well as informative is his self-deprecating and somewhat flippant manner of explaining some pretty esoteric theories and his own obsession with the topic.
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Wolman's book offers an informative and often humorous look at southpaws.