Wolfram-like syndrome autosomal dominant

Wolfram-like syndrome autosomal dominant

A condition (OMIM:614296) characterised by the clinical triad of congenital progressive hearing impairment (of low- and middle-frequency ranges, with onset in the first decade of life), diabetes mellitus and optic atrophy.

Molecular pathology
Defects of WFS1, which encodes a transmembrane protein that regulates Ca2+ homeostasis, cause Wolfram-like syndrome autosomal dominant.
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