Wolfram syndrome


Also found in: Acronyms, Wikipedia.

DIDMOAD syndrome

acronymic syndrome of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, of uncertain cause.
Synonym(s): Wolfram syndrome

Wolfram syndrome

[wool′frəm]
Etymology: D.J. Wolfram, American physician, 20th century
an autosomal-recessive syndrome, first evident in childhood, consisting of diabetes mellitus, diabetes insipidus, optic atrophy, and neural deafness. Also called DIDMOAD syndrome.
An autosomal recessive [MIM 222300] condition characterised by diabetes insipidus, non-autoimmune type 1 diabetes mellitus, optic atrophy, sensorineural deafness and further neurological and endocrinological abnormalities. Death occurs prematurely, often from respiratory failure associated with brainstem atrophy

Wolf·ram syn·drome

(wulf'răm sin'drōm)
A disorder consisting of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness; the genetic abnormality is located on chromosome 4p; autosomal recessive inheritance.

Wolfram,

Donald J., U.S. physician, 1910–.
Wolfram syndrome - autosomal recessive disorder characterized by juvenile diabetes mellitus and optic atrophy. The acronym DIDMOAD is used to describe the syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness).
References in periodicals archive ?
It was only when Krystle needed n glasses when she was ten that Wolfram syndrome was diagnosed.
He went out of the room and when he came back in he said he was sure our daughter had Wolfram syndrome but we'd need to go to the diabetic doctor to find out.
Last month, Wolfram Syndrome UK launched their 2014 national awareness campaign in the form of a charity road trip, where teams visited all 25 major children's hospitals across Britain, including Yorkhill in Glasgow, travelling 9000 miles in less than 60 hours.
The researchers were studying the epidemiology of Wolfram syndrome when they first noticed an excess of psychiatric symptoms among relatives of those with the disorder.
Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute and Columbia University Medical Center (CUMC) produced induced pluripotent stem (iPS) cells from skin samples from individuals with Wolfram syndrome.
Wolfram syndrome is an often fatal genetic disorder characterized by the development of insulin-dependent diabetes, vision loss, and deafness.