Wolfram syndrome


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DIDMOAD syndrome

acronymic syndrome of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, of uncertain cause.
Synonym(s): Wolfram syndrome
Farlex Partner Medical Dictionary © Farlex 2012
An autosomal recessive [MIM 222300] condition characterised by diabetes insipidus, non-autoimmune type 1 diabetes mellitus, optic atrophy, sensorineural deafness and further neurological and endocrinological abnormalities. Death occurs prematurely, often from respiratory failure associated with brainstem atrophy
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Wolf·ram syn·drome

(wulf'răm sin'drōm)
A disorder consisting of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness; the genetic abnormality is located on chromosome 4p; autosomal recessive inheritance.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Wolfram,

Donald J., U.S. physician, 1910–.
Wolfram syndrome - autosomal recessive disorder characterized by juvenile diabetes mellitus and optic atrophy. The acronym DIDMOAD is used to describe the syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness).
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Baz et al., "Diabetes mellitus and optic atrophy: A study of Wolfram syndrome in the Lebanese population," The Journal of Clinical Endocrinology & Metabolism, vol.
Swift, "Psychiatric findings in Wolfram syndrome homozygotes," The Lancet, vol.
Wolfram syndrome (WS), also named diabetes insipidus, diabetes mellitus, optic atrophy, and deafness (DIDMOAD) syndrome, is a rare autosomal recessive disorder.
It was only when Krystle needed new '." It was only when Krystle needed n glasses when she was ten that Wolfram syndrome was diagnosed.
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome).
Swift, "Psychiatric disorders and mutations at the Wolfram syndrome locus," Biological Psychiatry, vol.
The researchers were studying the epidemiology of Wolfram syndrome when they first noticed an excess of psychiatric symptoms among relatives of those with the disorder.
Commonest type of wolfram syndrome is because of mutation in chromosome 4 (4p16).
Wolfram syndrome in the Japanese population; molecular analysis of WFS1 gene and characterization of clinical features.
Wolfram syndrome is an often fatal genetic disorder characterized by the development of insulin-dependent diabetes, vision loss, and deafness.
Deletion of mitochondrial DNA in a case of early onset diabetes mellitus, optic atrophy, and deafness (Wolfram syndrome, MIM 222300).