Wolfram syndrome

(redirected from Wolfram's syndrome)

DIDMOAD syndrome

acronymic syndrome of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, of uncertain cause.
Synonym(s): Wolfram syndrome
An autosomal recessive [MIM 222300] condition characterised by diabetes insipidus, non-autoimmune type 1 diabetes mellitus, optic atrophy, sensorineural deafness and further neurological and endocrinological abnormalities. Death occurs prematurely, often from respiratory failure associated with brainstem atrophy

Wolf·ram syn·drome

(wulf'răm sin'drōm)
A disorder consisting of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness; the genetic abnormality is located on chromosome 4p; autosomal recessive inheritance.

Wolfram,

Donald J., U.S. physician, 1910–.
Wolfram syndrome - autosomal recessive disorder characterized by juvenile diabetes mellitus and optic atrophy. The acronym DIDMOAD is used to describe the syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness).
References in periodicals archive ?
MANF's lead indications are Parkinson's disease, diabetes, Wolfram's syndrome, Alzheimer's disease, traumatic brain injury (TBI), myocardial infarction, antibiotic-induced ototoxicity and certain other rare orphan diseases currently under consideration.
Wolfram's Syndrome is a rare, genetic pediatric condition characterized by Type-1 diabetes, blindness due to optic atrophy, deafness and neurodegeneration that affects an estimated 20,000 patients worldwide, including 1,000 in the US.
There may be well recognised clinical features suggesting specific mitochondrial DNA defect and these include Pearson marrow pancreas syndrome, Wolfram's syndrome, MELAS (Myoencephalopathy, lactic acidosis and stroke like episodes), Kearn-Sayre syndrome and MLASA (Myopathy, lactic acidosis and sideroblastic anemia)3.