Wolf-Hirschhorn syndrome


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Wolf-Hirschhorn syndrome

 [woolf´hirsh´horn]
a syndrome associated with partial deletion of the short arm of chromosome 4, characterized by an undersized head, increased distance between the eyes, epicanthus, cleft palate, a small receding mandible, low-set ears that are simplified in form, undescended testes, and hypospadias.
Facial view of a 3-year-old child with the Wolf-Hirschhorn syndrome. From Mueller and Young, 2001.
An autosomal dominant [MIM 194190] chromosome deletion complex characterised by low birth weight, microcephaly, ‘Greek helmet’ facies—micrognathia, hypertelorism, epicanthus, beaked nose, redundant lateral nasal folds, cleft palate—inguinal hernia, cryptorchism, hypospadias and death before age 3

Wolf-Hirschhorn syndrome

(woolf′-hirsh′horn″)
[Kurt Hirschhorn, Austrian-born U.S. geneticist, b. 1926; Ulrich Wolf, Ger. geneticist, b. 1933]
,

WHS

A relatively rare disorder caused by a deletion of the short arm of chromosome 4, which results in the absence of a fibroblast growth factor receptor. Its clinical hallmarks include abnormal facial development, delays in attaining neurological and behavioral milestones, mental retardation, short stature, and heart defects. Affected children often succumb to the disease in the first years of life.
References in periodicals archive ?
Microarray and FISH-based genotype-phenotype analysis of 22 Japanese patients with Wolf-Hirschhorn syndrome.
Letm1, the mitochondrial Ca [sup]2+ /H [sup]+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Genotype-phenotype correlation in 21 patients with Wolf-Hirschhorn syndrome using high resolution array comparative genome hybridisation (CGH).
3 microduplication by MLPA and aCGH in a fetus from a family with Wolf-Hirschhorn syndrome.
Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2.
Wolf-Hirschhorn syndrome is caused by a missing section of genetic information from a chromosome and there is a wide variation in the degree of problems encountered by its victims.