Also found in: Dictionary, Thesaurus, Encyclopedia.


trademark for a preparation of stanozolol, an anabolic steroid used to prevent attacks of hereditary angioedema.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

anabolic steroid

A drug or hormone-like substance chemically or pharmacologically related to 17-α-alkylated testosterone that promotes muscle growth, which are commonly abused by athletes. Lipid changes by ASs are more marked with oral stanazol (manufactured for horses) than with IV testosterone; it decreases HDL-C (especially HDL2) and increases hepatic TG lipase (HDL) catabolism.
Children, adolescents with delayed puberty, decreased growth, small penis, hypogonadism, testosterone deficiency, osteoporosis management, aplastic anaemia, endometriosis, angioedema, sports performance enhancement (no longer legal), relief and recovery from common injuries, rehabilitation, weight control, anti-insomnia, and regulation of sexuality, aggression and cognition.

Oral, parenteral.
Metabolic effects
Increased protein synthesis and amino acid consumption, androgenesis, catabolism and gluticocototitosis.
Adverse effects (men)
Breast enlargement (gynecomastia), testicular atrophy, sterility, sperm abnormalities, impotence, prostatic hypertrophy, myocardial hypertrophy and fibrosis, myocardial infarction and fatal arrhythmias, peliosis hepatis, cholestasis, hepatic adenomas, testicular atrophy, peripheral oedema, intracerebral thrombosis.

Adverse effects (women)
Clitoral hypertrophy, beard growth, baldness, deepened voice, decreased breast size.

Adverse effects (men and women)
Aggression and antisocial behavior, increased risk of cardiovascular disease, peliosis hepatis, haemorrhage, jaundice, acne, accelerated bone maturation resulting in short stature, liver tumours (hepatic adenomas and CA) which may regress with abstinence; AS abusers are at an increased risk for HIV transmission, given the common practice of sharing of needles when injecting ASs.

ASs are detectable to 1 parts per billion 4 days after last use if the hormone is water-soluble, or 14 days after use in lipid-soluble compounds.

FDA status
ASs are schedule-III drugs per the Controlled Substances Act.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
"The Winstrol had nothing to do with it." But he'll still give Big Brown another dose on Sunday.
Haskin, admittedly a touch on the defensive, suggests we might be surprised by the number of top horses on Winstrol, "including big names who get much larger doses than Big Brown".
An admission by Big Brown's trainer Rick Dutrow that he gives all his horses a dose of Winstrol, a brand-name steroid, on the 15th of every month sparked an outcry last month.
Except that Dutrow, as noted by James Willoughby in a typically enlightening piece after the race, admitted in a TV broadcast watched by millions that he routinely uses steroids (trade name Winstrol) on his horses.
Which, in simple, inescapable terms, will be a magnificent equine athlete fatally compromised as a regular and permitted user of the anabolic steroid Stanozolol (trade name Winstrol) made infamous by 100m sprinter Ben Johnson in the 1988 Seoul Olympics.
Big Brown duly stormed home, and repeated the dose in the Preakness at Pimlico, where Dutrow observed just before the race: "I give all my horses Winstrol on the 15th of every month."
"I give all my horses Winstrol on the 15th of every month," the trainer said on NBC television shortly before the Preakness Stakes.
If a quote in the New York Daily News in a pre-Derby article is reliable, Dutrow said he used the steroid stanozolol (trade name Winstrol).