Wilms tumor


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Wilms tu·mor

(wilmz), Avoid the misspellings Wilm and Wilm's.
a malignant renal tumor of young children, composed of small spindle cells and various other types of tissue, including tubules and, in some cases, structures resembling fetal glomeruli and striated muscle and cartilage; often inherited as an autosomal dominant trait [MIM*194070, *194080, *194090].
Synonym(s): nephroblastoma

Wilms tu·mor

(vilmz tū'mŏr)
A malignant renal tumor of young children, composed of small spindle cells and various other types of tissue, including tubules and, in some cases, structures resembling fetal glomeruli, and striated muscle and cartilage. Often inherited as an autosomal dominant trait.
Synonym(s): nephroblastoma.

Wilms tumor

(vilmz)
[Max Wilms, Ger. surgeon, 1867–1918]
A rapidly developing tumor of the kidney that usually occurs in children. It is the most common renal tumor of childhood. It is associated with chromosomal deletions, esp. from chromosomes 11 and 16. In the past, the mortality from this type of cancer was extremely high; however, newer approaches to therapy have been very effective in controlling the tumor in about 90% of patients.
Synonym: embryonal carcinosarcoma; nephroblastoma

Wilms,

Max, German surgeon, 1867-1918.
Wilms syndrome - Synonym(s): Wilms tumor
Wilms tumor - a malignant renal tumor of young children. Synonym(s): adenomyosarcoma; embryoma of the kidney; nephroblastoma; Wilms syndrome
References in periodicals archive ?
Daley and Urbach's team found that they could reverse Lin28's tumor-causing effects in their transgenic model by forcing expression of Let-7, suggesting that treatments targeting Lin28 hold promise for treating Wilms tumors.
RESULTS: A slightly increased risk of Wilms tumor was found among children of mothers who reported insecticide use [odds ratio (OR) = 1.
Cases of Wilms tumor, rhabdomyosarcoma, and Ewing sarcoma were uniformly and unequivocally negative for this marker.
5) Wilms tumor 1 (WT-1), a common marker for Wilms tumor, may also be used to rule against a PNET diagnosis, (3,10) although in rare instances, it may also stain positive in renal PNETs.
Nasdaq: REGN) today announced that researchers from Columbia University and Regeneron Research Laboratories have reported that Regeneron's VEGF Trap caused shrinkage of established, growing tumors and their metastases in a mouse model of anaplastic Wilms Tumor, a highly aggressive kidney tumor which occurs most commonly in children.
4) Wilms tumor is the second most common pediatric malignant abdominal tumor and the most common primary pediatric renal malignancy.
11) Wilms tumor is a malignant embryonal neoplasm of nephrogenic blastemal cells.
Wilms tumor and hepatoblastoma can usually be cured if diagnosed early.
1) Like anaplastic Wilms tumors and malignant rhabdoid tumors of the kidney, CCSK is classified as a tumor with unfavorable histology by the National Wilms Tumor Study Group because of its propensity to metastasize to bone and recur years after the original diagnosis.
The two major groups in wilms tumor study are NWTS (National Wilms Tumor Study Group) which follows the upfront surgery principle and the SIOP (International Society of Pediatric Oncology) which follows the upfront chemotherapy principle in all stages of the disease.
To date, less than 30 cases of teratoid Wilms tumor have been reported in the literature [2], [3], [4]In a review, most of the patients were diagnosed between 2 to 4 years of age and 6 bilateral cases were observed.
Data from the National Wilms Tumor Study show that cellular mesoblastic nephroma is more common than classic mesoblastic nephroma by almost 3 to 1, and that cellular mesoblastic nephroma presents a few months later in life than classic mesoblastic nephroma.