Wilms tumor


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Wilms tu·mor

(wilmz), Avoid the misspellings Wilm and Wilm's.
a malignant renal tumor of young children, composed of small spindle cells and various other types of tissue, including tubules and, in some cases, structures resembling fetal glomeruli and striated muscle and cartilage; often inherited as an autosomal dominant trait [MIM*194070, *194080, *194090].
Synonym(s): nephroblastoma

Wilms tu·mor

(vilmz tū'mŏr)
A malignant renal tumor of young children, composed of small spindle cells and various other types of tissue, including tubules and, in some cases, structures resembling fetal glomeruli, and striated muscle and cartilage. Often inherited as an autosomal dominant trait.
Synonym(s): nephroblastoma.

Wilms tumor

(vilmz)
[Max Wilms, Ger. surgeon, 1867–1918]
A rapidly developing tumor of the kidney that usually occurs in children. It is the most common renal tumor of childhood. It is associated with chromosomal deletions, esp. from chromosomes 11 and 16. In the past, the mortality from this type of cancer was extremely high; however, newer approaches to therapy have been very effective in controlling the tumor in about 90% of patients.
Synonym: embryonal carcinosarcoma; nephroblastoma

Wilms,

Max, German surgeon, 1867-1918.
Wilms syndrome - Synonym(s): Wilms tumor
Wilms tumor - a malignant renal tumor of young children. Synonym(s): adenomyosarcoma; embryoma of the kidney; nephroblastoma; Wilms syndrome
References in periodicals archive ?
Wilms tumor (nephroblastoma) is an embryonal malignancy of the kidney.
Wilms tumor is usually diagnosed before the child reaches 5 years of age (Ries et al.
Cases were patients newly diagnosed with Wilms tumor < 16 years of age and treated at one of 128 participating hospitals in the United States and Canada from 1999 to 2002.
Low frequency of mutations in the WT1 coding region in Wilms tumor.
Alteration of hSNF5/ INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms tumor.
Results of the study showed that female survivors of Wilms tumor can go on to have healthy children so long as their entire pelvis is not treated with radiation therapy to cure their cancer.
The good news is that this study shows it is possible for women who received radiation therapy to the abdomen to treat Wilms tumor as a child can go on to have healthy babies," said John A.
Tissue, developmental and tumor-specific expression of divergent transcripts in Wilms tumor.
The Wilms tumor gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.
Metastatic Wilms tumor is excluded by confirming the absence of Wilms tumor in the kidneys.
Despite the absence of anaplastic histologic features, the patient died of local spread, supporting the contention that adult Wilms tumors tend to behave more aggressively than their pediatric counterparts even in extrauterine locations.
With the cytogenetic and molecular data present, some have proposed that the multidirectional differentiation is caused by fusion of the Ewing sarcoma gene and WT1 genes, leading to expression of neural features typical of the Ewing/ primitive neuroectodermal tumor family and predominantly epithelial differentiation of Wilms tumor.