Willebrand disease

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Willebrand disease

, von Willebrand disease (vil′ĕ-brant″)
[Erik Adolph von Willebrand, Finnish physician, 1870–1949]


A congenital autosomal dominant bleeding disorder caused by a deficiency of von Willebrand factor (a protein that helps platelets stick to injured blood vessels during the formation of blood clots. Inadequate amounts of the protein result in easy bruising or bleeding. Common symptoms of the disorder are frequent bleeding from the gums after brushing the teeth, frequent or prolonged nosebleeds, heavy menstrual periods, or heavy bleeding after childbirth or surgery.

The disease is the most common inherited bleeding disorder. Unlike hemophilia A and B, which are X-linked, it affects both genders. Despite its high prevalence in the population (about 3% of Americans are affected), vWD is often undiagnosed because many affected people have only mild episodes of bleeding. vWD can be diagnosed by the demonstration of low levels of von Willebrand factor in the blood; by a prolonged bleeding time; or by factor VIII deficiency (one function of von Willebrand factor is to carry clotting factor VIII in plasma). Treatments for heavy bleeding episodes (or for necessary surgeries) may include the administration of clotting factors containing von Willebrand factor or factor VIII or synthetic vasopressin.

References in periodicals archive ?
Controversies in the diagnosis of type 1 von Willebrand disease.
Biotechnology company Shire plc (LSE:SHP) (Nasdaq:SHPG) reported on Wednesday the receipt of the European Medicines Agency's (EMA) approval for the Marketing Authorisation Application (MAA) for VEYVONDI for the treatment of von Willebrand Disease (VWD).
There are 1,500 registered cases of hemophilia in the Philippines and 30 of the Von Willebrand disease, said Villanueva, citing data from the Philippine Hemophilia Foundation.
Conclusion: There is high frequency of von Willebrand disease among females presenting with heavy menstrual bleeding in our set up.
Measurement of von Willebrand factor-FVIII binding activity in patients with suspected von Willebrand disease type 2N: application of an ELISA-based assay in a reference laboratory.
Validation of a new panel of automated chemiluminescence assays for von Willebrand factor antigen and activity in the screening for von Willebrand Disease.
Vonvendi is an important new option with the potential to redefine treatment for adults with von Willebrand disease," said Brian Goff, executive vice president and president of hematology at Baxter Inc.
I was diagnosed with von Willebrand Disease (vWD) around nine years ago, along with my now 16-year-old daughter Star.
von Willebrand disease (VWD), reportedly the most common bleeding disorder, arises from deficiency and/ or defects of von Willebrand factor (VWF).
Von Willebrand disease is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions.
Also, the Phase III study of BAX 111, the first recombinant treatment in clinical development for von Willebrand disease, met its primary efficacy endpoint, achieving pre-specified success in the on-demand treatment of bleeding events.