Willebrand disease


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Willebrand disease

, von Willebrand disease (vil′ĕ-brant″)
[Erik Adolph von Willebrand, Finnish physician, 1870–1949]
,

vWD

A congenital autosomal dominant bleeding disorder caused by a deficiency of von Willebrand factor (a protein that helps platelets stick to injured blood vessels during the formation of blood clots. Inadequate amounts of the protein result in easy bruising or bleeding. Common symptoms of the disorder are frequent bleeding from the gums after brushing the teeth, frequent or prolonged nosebleeds, heavy menstrual periods, or heavy bleeding after childbirth or surgery.

The disease is the most common inherited bleeding disorder. Unlike hemophilia A and B, which are X-linked, it affects both genders. Despite its high prevalence in the population (about 3% of Americans are affected), vWD is often undiagnosed because many affected people have only mild episodes of bleeding. vWD can be diagnosed by the demonstration of low levels of von Willebrand factor in the blood; by a prolonged bleeding time; or by factor VIII deficiency (one function of von Willebrand factor is to carry clotting factor VIII in plasma). Treatments for heavy bleeding episodes (or for necessary surgeries) may include the administration of clotting factors containing von Willebrand factor or factor VIII or synthetic vasopressin.

References in periodicals archive ?
Since starting its “Education is Power” scholarship program in 2006, MedPro Rx has distributed more than $340,000 to students nationwide who have either hemophilia or von Willebrand Disease (vWD).
ABBREVIATIONS: ADP = adenosine diphosphate; BSS = Bernard-Soulier syndrome; GP = glycoprotein; GSA = guanidinosuccinic oxide MPDs = myeloproliferative disorders; NO = nitric oxide; NSAIDs = non-steroidal anti-inflammatory drugs; [TXA.sub.2] = thromboxane AZ; VWD = von Willebrand disease; VWF = von Willebrand factor.
Laboratory testing for von Willebrand disease: contribution of multimer analysis to diagnosis and classification.
Tests for von Willebrand factor antigen and von Willebrand factor ristocetin cofactor showed normal values, thereby excluding von Willebrand disease. Therefore, the strikingly impaired factor VIII activity was most likely caused by an acquired factor VIII inhibitor.
This fully automated chemiluminescent immunoassay is indicated for the quantitative determination of VWF collagen-binding activity in human citrated plasma on the ACL AcuStar Hemostasis Testing System to aid in the investigation of von Willebrand Disease (VWD).
Patients with isolated hemophilia A, B, or C (due to deficiencies in factors VIII, IX, and XI, respectively) or factor VIII deficiency due to von Willebrand disease typically have a prolonged aPTT but a normal PT.
(ACHC), and URAC (In-Process) provider emphasizes treatments for individuals with autoimmune neuromuscular disorders as well as rare bleeding disorders, such as hemophilia and von Willebrand Disease. The pharmacy has received numerous awards for its success and was recognized with the 2011 No.
This means that a concentrate for the treatment of patients with von Willebrand disease per unit of factor VIII should be at least one unit of von Willebrand factor.
Abnormalities in vWF activity, most often related to abnormal concentration or multimer distribution, are the incident cause of the group of coagulopathies known as von Willebrand disease (vWD) (1, 2).
Contract notice: Von willebrand disease is moderate for the treatment of congenital hemophilia, hemophilia a, 2016, the acquisition of a suitable formulation to treat immune tolerance induction.
Defects in the VWF molecule can lead to von Willebrand disease (VWD), a common bleeding disorder that affects 1% to 3% of the general population.
Contract awarded for Summary of tender results: ITB UKR/2015/122 Procurement of medicines for children with hemophilia A and B or Willebrand disease for the National Public Health Programme to the Ministry of Health (MoH) in Ukraine:1.