Willebrand


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Wil·le·brand

(vil'ĕ-brahnt),
E.A. von. See: von Willebrand.
Farlex Partner Medical Dictionary © Farlex 2012

von Willebrand,

Erik Adolph, Finnish physician, 1870-1949.
von Willebrand disease - a hemorrhagic diathesis characterized by the tendency to bleed primarily from mucous membranes.
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Hajage et al., "ADAMTS-13 and von Willebrand factor predict venous thromboembolism in patients with cancer," Journal of Thrombosis and Haemostasis, vol.
Von Willebrand syndrome is a deficiency or dysfunction of von Willebrand factor (vWF), a protein with binding sites for platelets, collagen, and factor VIII that "serves as a bridge between platelets and injury sites in vessel walls" and "protects factor VIII from rapid proteolytic degradation," Dr.
Studies have reported that half of the epistaxis patients had blood group O and blood group O was associated with a lower expression of vWF (Von Willebrand factor) [10, 11] as compared with non-O groups.
There are 1,500 registered cases of hemophilia in the Philippines and 30 of the Von Willebrand disease, said Villanueva, citing data from the Philippine Hemophilia Foundation.
Interestingly, on cultured ECs, the antiinflammatory effect of rADAMTS13 was reversed by recombinant von Willebrand factor (rVWF), suggesting that VWF mediates the effect of ADAMTS13 on vascular inflammation.
Laboratory evaluation confirmed type 1 VWD with ristocetin cofactor activity of 38%, von Willebrand antigen level of 41%, factor VIII level of 60%, and a normal von Willebrand factor multimer distribution.
Types of bleeding disorders that may present with epistaxis include coagulation factor deficiencies, Von Willebrand disease, and several rare inherited platelet function disorders associated with defects in specific aspects of platelet function (Table 1).
Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF: ristocetin cofactor assay, and negative Bethesda assay, indicating acquired von Willebrand disease.
Recognition of acquired von Willebrand syndrome (AVWS) and its many causes, including malignancy, is important and a high level of suspicion for AVWS must be maintained in the workup of bleeding disorders.
Objective: To determine the frequency of Von Willebrand disease (vWD) in patients of heavy menstrual bleeding (HMB).