The researchers estimated that there may be as much as a three-and-a-half-year delay in progression of Alzheimer's disease in people who have eaten a Mediterranean diet for many years, rather than a standard Western diet
. Research that involves larger and more diverse groups of people over longer periods of time is needed to confirm these findings.
The Western diet
was linked with a higher risk of gout, so changing it may be a preventive approach for those at risk.
Interestingly, in addition to the acute inflammatory response, this also has long-term consequences for the immune system's responses: The activation by Western diet
changes the way in which the genetic information is packaged.
Thioglycollate-elicited peritoneal macrophages or livers were harvested from [LDLR.sup.-/-] and [LDLR.sup.-/-]; [macLRP1.sup.-/-] mice fed a standard chow or Western diet
. Total RNA was isolated using TRIzol[TM] Reagent (Invitrogen 15596026) as directed by the manufacturer.
Green tea isn't part of a normal Western diet
, but starting to drink the medicinal tea influences our health for the better, as further research focuses on EGCG's effects on our mind and body.
At 10 weeks of age, 3 separate cohorts of mice were started on either control diet (Cat number 98052602; Research Diets Inc., New Brunswick, NJ) or Western diet
(Cat number D12079B; Research Diets Inc.) for 4, 12, and 20 weeks.
The mice didn't gain much weight or have changes in insulin or cholesterol no matter what they ate: a fat-and-carbohydrate-laden Western diet
, traditional Mediterranean or Japanese diets (usually considered healthy) or low-carbohydrate, fat-rich fare known as the ketogenic diet.
The benefits that come from eating a Mediterranean-style diet do not exist with a traditional Western diet
, which tends to include more red meat, processed foods, sodium, refined grains, unhealthy fats (saturated and trans) and added sugars.
The Western diet
was defined by the researchers as high in fat, sugar and cholesterol.
They discuss the effects of various diets on metabolic changes in visceral organs and the brain, focusing on the Western diet
, Mediterranean diet, ketogenic diets, n-3 fatty acids, homocysteine levels, polyphenols, and table salt; the effects of diet and exercise on major depression, diabetic retinopathy, age-induced impairments, cognitive function, dementia, Alzheimer's disease, neural plasticity, the aging brain, neuronal survival, anxiety disorders, neurodegenerative diseases, and neuroplasticity and growth factors in adolescence; and the role of sleep and its interaction with exercise.
The investigators reported that men who most closely adhered to a Western diet
were 2Vz times more likely to die from prostate cancer and 67 percent more likely to die from all causes compared to those who followed the diet the least.
Conversely, after two weeks, Africans who ate the Western diet
experienced changes in gut bacteria consistent with an increased risk.