Wernicke-Korsakoff syndrome


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Related to Wernicke-Korsakoff syndrome: Wernicke's encephalopathy, thiamine, pellagra, beriberi

Wernicke-Korsakoff syndrome

 [ver´nĭ-kĕ kor´sah-kof€]
a disorder of the central nervous system, usually associated with chronic alcoholism and nutritional deficiency such as severe thiamine depletion. It is characterized by a combination of motor and sensory disturbances (wernicke's encephalopathy) and disordered memory function (korsakoff's syndrome). It typically has an abrupt onset, manifested by ocular motility, ataxia, diplopia, and horizontal nystagmus. Many patients are unaware of their unsteady gait, decreased mental acuity, and other signs of cognitive dysfunction.



There usually is an immediate improvement in ocular disturbances once therapy with thiamine is begun. The ataxia and diminished perceptual function and concept formation show a much slower rate of improvement. Only about 20 per cent of those with Korsakoff's syndrome fully recover. The mortality rate for the syndrome may be as high as 17 per cent during the acute phase. (See also alcoholism.)
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Wer·nic·ke-Kor·sa·koff syn·drome

(vern'ik-ĕ kōr'să-kof), [MIM*277730]
the coexistence of Wernicke and Korsakoff syndromes, with characteristic lesions in the mammilary bodies and medial dorsal thalamic nucleus.

Wer·nic·ke-Kor·sa·koff syn·drome

(vern'ik-ĕ kōr'să-kof), [MIM*277730]
the coexistence of Wernicke and Korsakoff syndromes, with characteristic lesions in the mammilary bodies and medial dorsal thalamic nucleus.
Farlex Partner Medical Dictionary © Farlex 2012

Wernicke-Korsakoff syndrome

(vĕr′nĭ-kē-kôr′sə-kôf′, -kŏf′, -nĭ-kə-)
n.
A neurological disorder usually associated with severe alcoholism and subsequent thiamine deficiency, marked by the signs of Wernicke's encephalopathy in the acute phase followed by the chronic memory loss and disorientation of Korsakoff syndrome.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Wernicke-Korsakoff syndrome

Alcoholic encephalopathy, Korsakoff psychosis, Wernicke's disease Neurology Organic mental disease linked to chronic alcohol abuse, usually accompanied by thiamin deficiency Clinical Memory loss, confabulation
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Wer·nic·ke-Kor·sa·koff syn·drome

(ver'ni-kĕ-kōr'sĕ-kof sin'drōm)
The coexistence of Wernicke and Korsakoff syndromes.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Wernicke-Korsakoff syndrome

A late form of brain damage occurring in long-term alcoholics who rely mainly on alcohol for nutrition and who are severely deficient in the B vitamin thiamine. One form, Wernicke's encephalopathy, starts suddenly with incoordination, staggering, paralysis of eye movements and mental confusion progressing to stupor and death. Patients can be saved by a timely injection of a large dose of thiamine. The other form, Korsakoff's psychosis, features severe memory loss with inability to store new data and a process of confabulation, in which the affected person makes up stories to fill in the gaps in the memory. Korsakoff's psychosis is usually irreversible and proceeds to profound DEMENTIA. (Karl Wernicke, 1848–1904, German neurologist; and Sergei Sergeivitch Korsakov, 1853–1900, Russian psychiatrist and neurologist).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Wernicke-Korsakoff syndrome

A combination of symptoms, including eye-movement problems, tremors, and confusion, that is caused by a lack of the B vitamin thiamine and may be seen in alcoholics.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Korsakoff,

(Korsakov), Sergei S., Russian neurologist and psychiatrist, 1853-1900.
Korsakoff psychosis - Synonym(s): Korsakoff syndrome
Korsakoff syndrome - an alcohol amnestic syndrome. Synonym(s): amnestic psychosis; amnestic syndrome; dysmnesic psychosis; Korsakoff psychosis; polyneuritic psychosis
Wernicke-Korsakoff encephalopathy
Wernicke-Korsakoff syndrome - see under Wernicke

Wernicke,

Karl, German neurologist, 1848-1905.
Gayet-Wernicke syndrome - Synonym(s): Wernicke syndrome
Wernicke aphasia - impairment in the comprehension of spoken and written words. Synonym(s): Bastian aphasia; sensory aphasia
Wernicke area - Synonym(s): Wernicke center
Wernicke center - the region of the cerebral cortex thought to be essential for understanding and formulating coherent, propositional speech. Synonym(s): sensory speech center; Wernicke area; Wernicke field; Wernicke region; Wernicke zone
Wernicke cramp - psychogenic muscle cramp. Synonym(s): cramp neurosis
Wernicke disease - Synonym(s): Wernicke syndrome
Wernicke encephalopathy - Synonym(s): Wernicke syndrome
Wernicke field - Synonym(s): Wernicke center
Wernicke radiation - the massive, fanlike fiber system passing from the lateral geniculate body of the thalamus to the visual cortex. Synonym(s): optic radiation
Wernicke reaction - in hemianopia, a reaction due to damage of the optic tract, consisting in loss of pupillary constriction when the light is directed to the blind side of the retina. Synonym(s): Wernicke sign
Wernicke region - Synonym(s): Wernicke center
Wernicke sign - Synonym(s): Wernicke reaction
Wernicke syndrome - a condition encountered in chronic alcoholics, characterized by disturbances in ocular motility, pupillary alterations, nystagmus, and ataxia with tremors. Synonym(s): Gayet disease; Gayet-Wernicke syndrome; superior hemorrhagic polioencephalitis; Wernicke disease; Wernicke encephalopathy
Wernicke zone - Synonym(s): Wernicke center
Wernicke-Korsakoff encephalopathy
Wernicke-Korsakoff syndrome - the coexistence of Wernicke and Korsakoff syndromes.
Wernicke-Mann hemiplegia - extremity hemiplegia that is partial. Synonym(s): Wernicke-Mann paralysis
Wernicke-Mann paralysis - Synonym(s): Wernicke-Mann hemiplegia
Medical Eponyms © Farlex 2012

Wer·nic·ke-Kor·sa·koff syn·drome

(ver'ni-kĕ-kōr'sĕ-kof sin'drōm) [MIM*277730]
The coexistence of Wernicke and Korsakoff syndromes.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Neuroimaging of the Wernicke-Korsakoff syndrome. Alcohol Alcohol.
Neural correlate of anterograde amnesia in Wernicke-Korsakoff syndrome. Brain Topography 28(5):760-770, 2015.PMID:25148770
The history of alcohol abuse and mildly elevated hepatic function tests suggest a substance use disorder such as Wernicke-Korsakoff syndrome or a withdrawal syndrome.
Separating cognitive impairment in neurologically asymptomatic alcoholism from Wernicke-Korsakoff Syndrome: Is the neurological distinction justified?
Alcohol-related damage to this structure is presumed to be responsible for the truncal and lower-limb motor deficits that cause lack of coordination and are observed commonly in patients with Wernicke-Korsakoff Syndrome' (Victor et al.
Thiamine deficiency can cause Wernicke syndrome (also called Wernicke-Korsakoff syndrome), which is a disorder of the nervous system characterized by confusion, gait abnormalities, and paralysis of certain eye muscles.
Dehydration Pellagra (B-6 deficiency) Thiamine deficiency (Wernicke-Korsakoff syndrome) Cobalamin deficiency (B-12) or ernicious anemia Folate deficiency Marchiafave-Bignami disease
Examples of such conditions include alcohol-induced persisting amnesic disorder (also called Wernicke-Korsakoff syndrome) and dementia, which seriously affects many mental functions in addition to memory (e.g., language, reasoning, and problem-solving abilities) (Rourke and Loberg 1996).
Although his initial presentation was consistent with delirium, the lack of an identifiable medical cause, prolonged time course, and lack of improvement with dopamine blocking agents suggest additional diagnoses such as Wernicke-Korsakoff syndrome, rapidly progressive dementia, or a substance-induced disorder.
Because intermediate products of these pathways are needed for the generation of other essential molecules in the cells (e.g., building blocks of proteins and DNA as well as brain chemicals), a reduction in thiamine can interfere with numerous cellular functions, leading to serious brain disorders, including Wernicke-Korsakoff syndrome, which is found predominantly in alcoholics.