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premature aging in the adult, transmitted as an autosomal recessive trait, and characterized principally by sclerodermalike skin changes, involving especially the extremities, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, white hair and/or baldness, and a high incidence of neoplasms.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Werner's syndromeA hereditary, probably autosomal recessive, condition featuring dwarfism, premature ageing, atrophy of the skin, CATARACTS, severe arterial disease, OSTEOPOROSIS, atrophy of the testicles and DIABETES. The condition features accelerated TELOMERE shortening and mutation causing a defect in the DNA helicase protein. (C. W. Otto Werner, b. 1879, German physician).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005