Werner's syndrome is an autosomal recessive disorder first described in 1904 and, with an estimated prevalence rate of 1-10 per million population, being more common in Japan and Sardinia.
In progeria and Werner's syndrome most biochemical abnormalities are associated with connective tissue, principally of mesodermal origin.
This compares with 10-20% of glycosaminoglycan content in Werner's syndrome .
Cultured cells from patients with Werner's syndrome contain normal levels of superoxide dismutase and glutathione peroxidase  and the rate of lipid peroxidation is normal.
Cultured fibroblasts from patients with progeria and Werner's syndrome show a markedly reduced potential for in vitro growth and have a shorter replicative life span compared with control cultures .
Recently, an exciting development has been the identification of the gene defect responsible for Werner's syndrome on chromosome 8 .
Thus, the occurrence of higher rates of malignancy in this condition and Werner's syndrome are likely to be due to chromosomal abnormalities resulting from reduced cell cycle regulation .